82156-66-9

Basic information

• Product Name: ethyl 4-bromo-3-hydroxy-3-(2-hydroxyphenyl)butyrate
• CAS NO: 82156-66-9
• Molecular Weight: 303.153
• Mol File: 82156-66-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 4-bromo-3-hydroxy-3-(2-hydroxyphenyl)butyrate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-bromo-3-hydroxy-3-(2-hydroxyphenyl)butyrate(82156-66-9)
• EPA Substance Registry System: ethyl 4-bromo-3-hydroxy-3-(2-hydroxyphenyl)butyrate(82156-66-9)

Safety Data

• Hazardous Substances Data: 82156-66-9(Hazardous Substances Data)

Upstream product

• 13176-46-0 4-bromoethyl acetoacetate 
• 108-95-2 phenol 

Downstream Products

• 82156-58-9 benzofuran-3-yl-acetic acid ethyl ester 

Relevant articles and documents

Reaction of 4-Haloacetoacetate with Phenols in the Presence of Aluminium Chloride

Reaction of ethyl 4-bromoacetoacetate (1) with phenol in the presence of aluminium chloride gave ethyl 4-bromo-3-hydroxy-3-(2-hydroxyphenyl)butyrate (3a), which can be regarded as an intermediate of the Pechmann reaction.Similar reaction of ethyl 4-chloroacetoacetate (7) with phenol in the presence of aluminium chloride gave the 4-chloro derivative 8a.Compound 3a was treated with either hydrogen chloride in ethanol or triethylamine followed by treatment with p-toluenesulfonic acid to give 4-bromomethylcoumarin (4a) or ethyl 3-benzofuranacetate (6a), respectively.Similarly, reactions of phenol derivatives 2 with 1 gave the corresponding 3-hydroxybutyrates 3, which were transformed to the coumarins 4 and the 3-benzofuranacetates 6.