821794-90-5 Usage
Description
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone is a complex organic compound characterized by its off-white to pale yellow solid appearance. It features a unique molecular structure that includes an amino group, a hydroxypropyl chain, a methylphenyl group, and a pyrrolo[2,3-d]pyrimidinyl moiety, all of which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone is used as a key intermediate in the synthesis of serine/threonine kinase inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various diseases, including cancer and inflammatory disorders. 1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone's unique structure allows it to interact with specific kinases, modulating their activity and potentially leading to therapeutic benefits.
Used in Research and Development:
In addition to its pharmaceutical applications, 1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone is also utilized in research and development settings. Scientists and chemists use this compound to study the structure-activity relationships of kinase inhibitors, as well as to develop new synthetic methods and strategies for the preparation of biologically active molecules.
Used in Drug Design and Optimization:
1-[4-AMino-7-(3-hydroxypropyl)-5-(4-Methylphenyl)-7H-pyrrolo[2,3-d]pyriMidin-6-yl]-2-chloro-ethanone's unique structural features make it a valuable tool in drug design and optimization processes. By incorporating this molecule into the design of new drugs, researchers can potentially improve the potency, selectivity, and pharmacokinetic properties of serine/threonine kinase inhibitors. This can lead to the development of more effective and safer therapeutic agents for the treatment of various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 821794-90-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,1,7,9 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 821794-90:
(8*8)+(7*2)+(6*1)+(5*7)+(4*9)+(3*4)+(2*9)+(1*0)=185
185 % 10 = 5
So 821794-90-5 is a valid CAS Registry Number.
821794-90-5Relevant articles and documents
SELECTIVE SERINE/THREONINE KINASE INHIBITORS
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Page/Page column 27; 32, (2008/06/13)
Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
