82231-59-2

Basic information

• Product Name: 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester
• Synonyms: 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester;ethyl (4-iodo-1H-pyrazol-1-yl)acetate;ethyl 2-(4-iodo-1H-pyrazol-1-yl)acetate;(4-Iodo-pyrazol-1-yl)-acetic acid ethyl ester
• CAS NO: 82231-59-2
• Molecular Formula: C7H9IN2O2
• Molecular Weight: 280.06303
• Mol File: 82231-59-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 320.6±22.0 °C(Predicted)
• Appearance: /
• Density: 1.83±0.1 g/cm3(Predicted)
• PKA: -0.25±0.10(Predicted)
• CAS DataBase Reference: 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester(82231-59-2)
• EPA Substance Registry System: 1H-pyrazole-1-acetic acid, 4-iodo-, ethyl ester(82231-59-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 82231-59-2(Hazardous Substances Data)

Usage

Uses

(4-Iodo-pyrazol-1-yl)-acetic Acid Ethyl Ester is used in the synthesis of autotaxin inhibitors.

Upstream product

• 3469-69-0 4-iodopyrazole 
• 105-36-2 ethyl bromoacetate 
• 542-58-5 2-chloro-1-acetoxyethane 

Relevant articles and documents

BTK inhibitor and preparation method and pharmaceutical application thereof

The invention relates to a compound as shown in a general formula (I) or a stereoisomer, a solvate, a prodrug, a metabolite, a pharmaceutically acceptable salt or eutectic thereof, and an intermediateand a preparation method thereof, and an application of the compound in BTK related diseases such as tumors or autoimmune system diseases. B-L-K (I).

HETEROCYCLIC AUTOTAXIN INHIBITORS AND USES THEREOF

Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other c