82258-55-7Relevant articles and documents
LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS
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Page/Page column 158, (2014/09/29)
This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1–R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
Process for the preparation of the PPAR alpha agonist NS-220
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Page/Page column 8, (2010/11/28)
The present invention is concerned with a novel process for the preparation of compounds of formula (I) wherein R1 and R2 are as defined in the description and claims. The compounds of formula (I) are pharmaceutically active substanc
The Synthesis of Octacidomycin
Kerber, Karl-Heinz,Lackner, Helmut
, p. 719 - 726 (2007/10/02)
The total synthesis of octacidomycin (1), a novel oligocarboxylic acid antibiotic, and some shorter new model acids (19, 21, 24) is described.Key compounds in a series of fragment condensations of C19-, C5- and C2-units are α,α'-bis(bromopentyl)-substituted azealic- (6) and 3-(benzyloxypropyl)malonic esters (7).A six step synthesis yields bacteriostatically active octacidomycin (14=1). 14 and its octamethyl ester 15 are identical with the native products in all chemical and spectroscopic properties.Further combinations of fragments give tri-, tetra-, and pentacarboxylic acids.These demonstrate the flexibility of this widely variable synthetic method leading to new carboxylic acids and hydrocarbons.
