82278-99-7

Basic information

• Product Name: DL-N-(TERT-BUTOXYCARBONYL)-3-METHOXYPHENYLALANINE
• Synonyms: DL-N-(TERT-BUTOXYCARBONYL)-3-METHOXYPHENYLALANINE;Boc-3-Methoxy-DL-phenylalanine;2-([(TERT-BUTOXY)CARBONYL]AMINO)-3-(3-METHOXYPHENYL)PROPANOIC ACID;N-Boc-DL-3-methoxy-Phenylalanine
• CAS NO: 82278-99-7
• Molecular Formula: C15H21NO5
• Molecular Weight: 295.333
• Mol File: 82278-99-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 461.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• PKA: 3.89±0.10(Predicted)
• CAS DataBase Reference: DL-N-(TERT-BUTOXYCARBONYL)-3-METHOXYPHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: DL-N-(TERT-BUTOXYCARBONYL)-3-METHOXYPHENYLALANINE(82278-99-7)
• EPA Substance Registry System: DL-N-(TERT-BUTOXYCARBONYL)-3-METHOXYPHENYLALANINE(82278-99-7)

Safety Data

• Hazardous Substances Data: 82278-99-7(Hazardous Substances Data)

Usage

General Description

DL-N-(tert-butoxycarbonyl)-3-methoxyphenylalanine is a chemical compound with the molecular formula C17H23NO5. It is a modified form of the amino acid phenylalanine, with a tert-butoxycarbonyl (Boc) protecting group attached to the amino group and a methoxy group attached to the phenyl ring. DL-N-(TERT-BUTOXYCARBONYL)-3-METHOXYPHENYLALANINE is commonly used in the synthesis of peptides and other organic compounds. The Boc protecting group is used to prevent unwanted reactions at the amino group during peptide synthesis, and the methoxy group provides additional steric hindrance and electronic effects. DL-N-(tert-butoxycarbonyl)-3-methoxyphenylalanine is important in the field of organic chemistry and pharmaceutical research for its role in the creation of peptide-based drugs and bioactive compounds.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 

Relevant articles and documents

INHIBITOR OF APOPTOSIS (IAP) PROTEIN ANTAGONISTS

Provided herein are compounds that modulate the activity of melanoma inhibitor of apoptosis (ML-IAP) protein, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure

A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted allophenylnorstatine [Apns: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] were designed and synthesized. From the structure-metabolism relationship of this type of HIV protease inhibitors, the compounds having para substitution of the phenyl ring of Apns and/or 2,6-disubstitution of the P2′ benzylamine were found to be able to avoid the P2 phenol glucuronidation that occurs with SM-319777 (formerly named JE-2147, KNI-764); one of the main metabolic pathways of SM-319777. These new analogues, such as SM-322377, had more desirable pharmacokinetic profiles and more potent antiviral activity against not only wild type HIV-1 but also the multi-drug-resistant HIV-1 than SM-319777.