82296-59-1

Basic information

• Product Name: 4-Dimethylcarbamoyl-3,3-dimethyl-butyric acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester
• CAS NO: 82296-59-1
• Molecular Weight: 324.42
• Mol File: 82296-59-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Dimethylcarbamoyl-3,3-dimethyl-butyric acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Dimethylcarbamoyl-3,3-dimethyl-butyric acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester(82296-59-1)
• EPA Substance Registry System: 4-Dimethylcarbamoyl-3,3-dimethyl-butyric acid (7R,7aR)-7-hydroxy-5,6,7,7a-tetrahydro-3H-pyrrolizin-1-ylmethyl ester(82296-59-1)

Safety Data

• Hazardous Substances Data: 82296-59-1(Hazardous Substances Data)

Upstream product

• 4160-82-1 3,3-dimethylglutaric anhydride 
• 68-12-2 N,N-dimethyl-formamide 
• 480-85-3 retronecine 

Relevant articles and documents

Pyrrolizidine Alkaloid Analoques. Synthesis of Eleven-membered Macrocyclic Diesters of Retronecine

Treatment of (+)-retronecine (1) with 3,3-disubstituted glutaric anhydride derivatives (2) yielded mixtures of the retronecine 7- and 9-monoesters, which were assayed by 1H n.m.r. spectrometry.Lactonisation of these mixtureswas achieved by the Corey-Nicolaou method to give a range of eleven-membered macrocyclic pyrrolizidine diesters (5) with different substituents at C-13.The macrocyclic nature of these pyrrolizidine alkaloid analogues was established by comparison of their 1H n.m.r. and mass spectra with those of natural pyrrolizidine alkaloids.