823195-13-7

Basic information

• Product Name: 1,3-Benzenedicarboxylic acid, 5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]-, diethyl ester
• CAS NO: 823195-13-7
• Molecular Formula: C18H16N2O5S
• Molecular Weight: 372.401
• Mol File: 823195-13-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenedicarboxylic acid, 5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenedicarboxylic acid, 5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]-, diethyl ester(823195-13-7)
• EPA Substance Registry System: 1,3-Benzenedicarboxylic acid, 5-[3-(2-thienyl)-1,2,4-oxadiazol-5-yl]-, diethyl ester(823195-13-7)

Safety Data

• Hazardous Substances Data: 823195-13-7(Hazardous Substances Data)

Upstream product

• 4105-93-5 1,3-bis(ethoxycarbonyl)benzoic acid 
• 53370-51-7 N-hydroxythiophene-2-carboximidamide 

Downstream Products

• 823195-24-0 (3-{1-[3-carbamoyl-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoyl]-piperidin-4-yl}-4-fluoro-benzyl)-carbamic acid tert-butyl ester 
• 823195-23-9 (3-{1-[3-carbamoyl-5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-benzoyl]-piperidin-4-yl}-benzyl)-carbamic acid tert-butyl ester 
• 823195-18-2 5-(3-thiophen-2-yl-[1,2,4]oxadiazol-5-yl)-isophthalamic acid 

Relevant articles and documents

Design of bivalent ligands using hydrogen bond linkers: Synthesis and evaluation of inhibitors for human β-tryptase

Alternative to a covalent linker, hydrogen bonds can be used to link ligands for maintaining simultaneous interactions with multiple binding sites. This is exemplified by the synthesis and evaluation of amide derivatives as potent inhibitors of human β-tryptase. We exploit the concept of using hydrogen bonds to link multiple ligands for maintaining simultaneous interactions with polyvalent binding sites. This approach is demonstrated by the syntheses and evaluation of pseudo-bivalent ligands as potent inhibitors of human β-tryptase.