823221-94-9

Basic information

• Product Name: 2-Bromo-6-chloro-4-(trifluoromethyl)pyridine
• Synonyms: 2-Bromo-6-chloro-4-(trifluoromethyl)pyridine
• CAS NO: 823221-94-9
• Molecular Formula: C6H2BrClF3N
• Molecular Weight: 260.4389896
• Mol File: 823221-94-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 68-70℃ (12 Torr)
• Appearance: /
• Density: 1.770 g/cm3
• Refractive Index: 1.4966 (589.3 nm 20℃)
• Storage Temp.: 2-8°C
• PKA: -4.51±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-6-chloro-4-(trifluoromethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-6-chloro-4-(trifluoromethyl)pyridine(823221-94-9)
• EPA Substance Registry System: 2-Bromo-6-chloro-4-(trifluoromethyl)pyridine(823221-94-9)

Safety Data

• Hazardous Substances Data: 823221-94-9(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-chloro-4-(trifluoromethyl)pyridine is a type of organic compound which falls under the category of halopyridines. Its molecular formula is C6H2BrClF3N. Known for its accurate pH value and purity, this compound has gained recognition in the field of chemical industry. Owing to its physical properties and nature, it is generally used as an intermediate in the production of various medical drugs or as a catalyst in a number of chemical reactions. It isn't purposed for food or drug use typically, and as with many chemicals of this nature, it should be handled carefully because of its potentially hazardous properties.

Upstream product

• 401892-47-5 5-bromo-4-iodo-2-chloropyridine 
• 53939-30-3 5-bromo-2-chloropyridine 
• 823221-93-8 5-bromo-2-chloro-4-(trifluoromethyl)pyridine 

Relevant articles and documents

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract