823222-03-3

Basic information

• Product Name: 2-Bromo-5-(trifluoromethyl)isonicotinic acid
• Synonyms: 2-Bromo-5-(trifluoromethyl)isonicotinic acid
• CAS NO: 823222-03-3
• Molecular Formula: C7H3BrF3NO2
• Molecular Weight: 270.01
• EINECS: -0
• Mol File: 823222-03-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-Bromo-5-(trifluoromethyl)isonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-(trifluoromethyl)isonicotinic acid(823222-03-3)
• EPA Substance Registry System: 2-Bromo-5-(trifluoromethyl)isonicotinic acid(823222-03-3)

Safety Data

• Hazardous Substances Data: 823222-03-3(Hazardous Substances Data)

Upstream product

• 505084-58-2 2-chloro-5-(trifluoromethyl)pyridine-4-carboxylic acid 

Relevant articles and documents

Logistic flexibility in the preparation of isomeric halopyridinecarboxylic acids

Although there are many conceivable ways to funtionalize, and specifically carboxylate, 2-chloro-4-(trifluoromethyl)pyridine optionally at all three vacant positions, it is more straightforward to prepare only the 2-chloro-4- (trifluoromethyl)pyridine-3-carboxylic acid (1) from this precursor and the other 6-chloro-4-(trifluoromethyl)pyridine-2- and -3-carboxylic acids (2 and 3) from a different one, viz. 5-bromo-2-chloro-4-(trifluoromethyl)pyridine. In the same manner, it proved more convenient to convert 5-chloro-2-(trifluoromethyl) pyridine in only two of the corresponding acids (6 and 7) and to make the third one (8) from 3-bromo-5-chloro-2-(trifluoromethyl)pyridine as an alternative starting material. All model substrates for functionalization were readily accessible from the correspondingly substituted chloroiodopyridine through heavy halogen displacement by in situ generated (trifluoromethyl)copper. Graphical Abstract