82378-91-4

Basic information

• Product Name: 4-acetamido-2-hydroxy-5-nitrobenzoic acid
• Synonyms: 4-acetamido-2-hydroxy-5-nitrobenzoic acid
• CAS NO: 82378-91-4
• Molecular Weight: 240.172
• Mol File: 82378-91-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-acetamido-2-hydroxy-5-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-acetamido-2-hydroxy-5-nitrobenzoic acid(82378-91-4)
• EPA Substance Registry System: 4-acetamido-2-hydroxy-5-nitrobenzoic acid(82378-91-4)

Safety Data

• Hazardous Substances Data: 82378-91-4(Hazardous Substances Data)

Upstream product

• 50-86-2 4-acetamidosalicylic acid 
• 65-49-6 4-Aminosalicylic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 1373526-56-7 4-(acetamido)-5-guanidino-2-hydroxybenzoic acid 
• 1374298-65-3 methyl 2-((2-chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate 
• 1374298-75-5 methyl 2-((2-chloro-6-fluorophenyl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxylate 
• 1374298-64-2 2-((2-chloro-6-methylphenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro-[4,5-d]imidazole-5-carboxylic acid 
• 1374298-71-1 2-((2-chloro-6-fluorophenyl)amino)-1,7,7-trimethyl-7,8-dihydro-1H-benzofuro-[4,5-d]imidazole-5-carboxylic acid 
• 1374296-71-5 2-((2,6-dichlorophenyl)amino)-N-(2,6-difluorophenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374296-70-4 2-((2,6-dichlorophenyl)amino)-7,7-dimethyl-N-(2-(trifluoromethyl)phenyl)-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374296-72-6 2-((2-chloro-6-fluorophenyl)amino)-7,7-dimethyl-N-(2-(trifluoromethyl)phenyl)-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-06-9 2-((2-chloro-6-fluorophenyl)amino)-N-(2-fluoro-5-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-26-3 2-((2-chloro-6-fluorophenyl)amino)-N-(5-(difluoromethyl)-2-fluorophenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-29-6 2-((2-chloro-6-fluorophenyl)amino)-N-(5-cyclopropyl-2-fluorophenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-54-7 N-(5-cyclopropyl-2-fluorophenyl)-2-((2,6-dichlorophenyl)amino)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-07-0 2-((2-chloro-6-fluorophenyl)amino)-N-(2-fluoro-4-(trifluoromethyl)phenyl)-7,7-dimethyl-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 
• 1374297-08-1 2-((2-chloro-6-fluorophenyl)amino)-7,7-dimethyl-N-(2-methyl-4-(trifluoromethyl)phenyl)-7,8-dihydro-1H-benzofuro[4,5-d]imidazole-5-carboxamide 

Relevant articles and documents

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Disclosed are 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives and manufactures thereof. The 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives are presented by formula (I): wherein R1 group is H, CH3, or C2H5; R2 group is H, or Br; R3 group is CH3, or C3H7; and R4 group is H, or C(═NH)—NH2. 4,5-diamino-3-halo-2-hydroxybenzoic acid derivatives provided here were non-toxic to MDCK cells, particularly compounds 6a, 6b, 6c, 6e, 6f, 7a, 7b and 8 had better anti-H1N1 activity. In the future, these compounds can be used to focus on viral neuraminidases as targets to develop effective anti-influenza drugs.