82476-04-8

Basic information

• Product Name: (E)-3-(2,4-dichlorophenyl)acryloyl chloride
• Synonyms: (E)-3-(2,4-dichlorophenyl)acryloyl chloride
• CAS NO: 82476-04-8
• Molecular Weight: 235.497
• Mol File: 82476-04-8.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: (E)-3-(2,4-dichlorophenyl)acryloyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2,4-dichlorophenyl)acryloyl chloride(82476-04-8)
• EPA Substance Registry System: (E)-3-(2,4-dichlorophenyl)acryloyl chloride(82476-04-8)

Safety Data

• Hazardous Substances Data: 82476-04-8(Hazardous Substances Data)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 29682-41-5 2,5-dichloroiodobenzene 
• 1201-99-6 trans-2,4-dichlorocinnamic acid 

Downstream Products

• 1237740-53-2 N-{3-[(E)-3-(2,4-dichlorophenyl)acryloyl]-5-isopropyl-1,3,5-oxadiazinan-4-ylidene}nitramide 
• 1237740-61-2 N-{3-[(E)-3-(2,4-dichlorophenyl)acryloyl]-5-methyl-1,3,5-oxadiazinan-4-ylidene}nitramide 
• 1237740-40-7 N-{3-[(E)-3-(2,4-dichlorophenyl)acryloyl]-5-ethyl-1,3,5-oxadiazinan-4-ylidene}nitramide 

Relevant articles and documents

Cinnamyl-containing rupestonic acid methyl ester derivative as well as preparation method and application of rupestonic acid methyl ester derivative

The invention relates to a cinnamyl-containing rupestonic acid methyl ester derivative as well as a preparation method and application thereof, the derivative is prepared by the following steps: reacting rupestonic acid with dimethyl sulfate to obtain rupestonic acid methyl ester, and then obtaining 2-hydroxyl rupestonic acid methyl ester under the oxidation of camphor sulfonyl acridine. and then reacting with cinnamyl chloride under the catalysis of DMAP to obtain 20 rupestonic acid methyl ester derivatives containing cinnamyl groups. The method has the advantages of mild reaction conditions and simple experimental steps. The obtained 1d-20d rupestonic acid methyl ester derivatives containing the cinnamyl groups are subjected to a preliminary in-vitro anti-influenza A H3N2 virus activity test. Experimental results show that the compounds show good activity in 7d, 15d and 18d, and can be used as drugs for resisting influenza A H3N2 virus.

Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI)

A novel series of di-carbonyl analogs of curcumin (DACs) were prepared and evaluated for their anti-inflammatory properties. Preliminary results showed that a vast majority of compounds tested in this study could effectively suppress LPS-induced production of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Structure-activity relationships of the compounds were discussed. Compounds 5a27 and 5a28 showed the most potent anti-inflammatory activities and had higher structural stability and orally bioavailability than curcumin in vitro. Mechanistically, they inhibited the activation of macrophages via the blockade of mitogen-activated protein kinase (MAPK) signaling and nuclear translocation of NF-κB. In vivo, 5a27 and 5a28 markedly alleviated lipopolysaccharides (LPS)-induced acute lung injury (ALI). The wet/dry ratio of lungs was significantly normalized by the active compounds, which was consistent with the suppression of neutrophil infiltration and production of proinflammatory cytokines. Collectively, these results present a new series of curcumin analogs as promising anti-inflammatory agents for treatment of ALI.

Lithocholic acid-3-oxime ester compound, and preparation method and application thereof

The invention discloses a lithocholic acid-3-oxime ester compound shown in a formula (I), and a preparation method thereof. The preparation method comprises the following steps: reacting substituted cinnamic acid and sulfoxide chloride to obtain substitut