824938-80-9

Basic information

• Product Name: TRANS-2-(PIPERIDIN-1-YL)CYCLOHEXANAMINE
• Synonyms: TRANS-2-(PIPERIDIN-1-YL)CYCLOHEXANAMINE
• CAS NO: 824938-80-9
• Molecular Formula: C11H22N2
• Molecular Weight: 182.31
• Mol File: 824938-80-9.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TRANS-2-(PIPERIDIN-1-YL)CYCLOHEXANAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-2-(PIPERIDIN-1-YL)CYCLOHEXANAMINE(824938-80-9)
• EPA Substance Registry System: TRANS-2-(PIPERIDIN-1-YL)CYCLOHEXANAMINE(824938-80-9)

Safety Data

• Hazardous Substances Data: 824938-80-9(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 71172-32-2 trans-1,2-dinitrocyclohexane 
• 7581-94-4 trans-2-(pipoeridin-1-yl)cyclohexanol 
• 286-20-4 cyclohexane-1,2-epoxide 
• 824938-91-2 N-[((1R,2R)-2-piperidin-1-yl)-cyclohexyl]acetamide 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 111-30-8 Glutaraldehyde 
• 1379686-03-9 N-[(1R,2R)-2-(piperidin-1-yl)cyclohexyl]benzamide 
• 1197208-38-0 N-((1R,2R)-2-aminocyclohexyl)benzamide 
• 111-24-0 1,5-dibromo-pentane 
• 320778-89-0 N-((1R,2R)-2-aminocyclohexyl)acetamide 
• 1611474-51-1 tert-butyl N-[(1R,2R)-2-(piperidin-1-yl)cyclohexyl]carbamate 
• 438588-60-4 2-((1R,2R)-2-aminocyclohexyl)isoindoline-1,3-dione 
• 146504-07-6 tert-butyl ((1R,2R)-2-aminocyclohexyl)carbamate 

Downstream Products

• 18468-91-2 (+/-)-N-(trans-2-piperidino-cyclohexyl)-benzamide 

Relevant articles and documents

Development of Chiral, Bifunctional Thiosquaramides: Enantioselective Michael Additions of Barbituric Acids to Nitroalkenes

We report a general method for the synthesis of chiral thiosquaramides, a class of bifunctional catalysts not previously described in the literature. Thiosquaramides are found to be more acidic and significantly more soluble in nonpolar solvents than their oxosquaramide counterparts, and they are excellent catalysts for the unreported, enantioselective conjugate addition reaction of the barbituric acid pharmacaphore to nitroalkenes, delivering the chiral barbiturate derivatives in high yields and high enantioselectivities, even with catalyst loadings as low as 0.05 mol%.

Kinetic Resolution of Acylsilane Cyanohydrins via Organocatalytic Cycloetherification

An asymmetric cyanation of acylsilanes involving the in-situ formation of chiral acylsilane cyanohydrins followed by their kinetic resolution via organocatalytic cycloetherification is described. The highly enantio- and diastereoselective cycloetherificat

Investigations towards the stereoselective organocatalyzed Michael addition of dimethyl malonate to a racemic nitroalkene: Possible route to the 4-methylpregabalin core structure

Chiral derivatives of γ-aminobutyric acid are widely used as medicines and can be obtained by organocatalytic Michael additions. We show here the stereoselective synthesis of 4-methylpregabalin stereoisomers using a Michael addition of dimethyl malonate to a racemic nitroalkene. The key step of the synthesis operates as a kinetic resolution with a chiral squaramide catalyst. Furthermore, specific organocatalysts can provide respective stereoisomers of the key Michael adduct in up to 99:1 er.