825-40-1

Basic information

• Product Name: 2-BROMO-4-CHLOROACETOPHENONE
• Synonyms: 4-ACETYL-3-BROMO-1-CHLOROBENZENE;1-(2-BROMO-4-CHLORO-PHENYL)-ETHANONE;Ethanone, 1-(2-bromo-4-chlorophenyl)-;1-(2-bromo-4-chlorophenyl)ethan-1-one
• CAS NO: 825-40-1
• Molecular Formula: C₈H₆BrClO
• Molecular Weight: 233.49
• Mol File: 825-40-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 44 °C
• Boiling Point: 297.2°C at 760 mmHg
• Flash Point: 133.6°C
• Appearance: /
• Density: 1.566g/cm³
• Vapor Pressure: 0.00137mmHg at 25°C
• Refractive Index: 1.569
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-4-CHLOROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4-CHLOROACETOPHENONE(825-40-1)
• EPA Substance Registry System: 2-BROMO-4-CHLOROACETOPHENONE(825-40-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 825-40-1(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-Chloroacetophenone is a chemical compound that belongs to the family of Acetophenones, and is used in several industrial applications. It is predominantly employed in the manufacturing of pharmaceuticals, organic intermediates, and dyes. The compound exhibits a light yellow to brownish appearance in form and is characterized by a ketone functional group located on the phenyl ring. Although it is generally safe when handled properly, exposure to 2-Bromo-4-Chloroacetophenone can potentially cause eye, skin, and respiratory tract irritation. It is also hazardous for aquatic life and should be disposed of responsibly.

InChI:InChI=1/C8H6BrClO/c1-5(11)7-3-2-6(10)4-8(7)9/h2-4H,1H3

Upstream product

• 84459-33-6 2-bromo-4-chlorobenzaldehyde 
• 1086601-87-7 1-(2-bromo-4-chlorophenyl)ethanol 
• 936-08-3 2-bromo-4-chlorobenzoic acid 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 59362-73-1 2-(bromomethyl)-4-(2-chlorophenyl)-2-(4-chlorophenyl)-1,3-dioxolane 
• 133111-56-5 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 
• 1326778-74-8 C₈H₇BrClNO 
• 1326778-61-3 (E)-1-(4-chloro-2-(phenylamino)phenyl)ethanone oxime 
• 1326778-62-4 (E)-1-(4-chloro-2-(p-tolylamino)phenyl)ethanone oxime 
• 1326778-63-5 (E)-1-(4-chloro-2-(4-chlorophenylamino)phenyl)ethanone oxime 
• 1326778-64-6 (E)-1-(4-chloro-2-(propylamino)phenyl)ethanone oxime 
• 1329166-57-5 (E)-tert-butyl 3-(2-acetyl-5-chlorophenyl)acrylate 
• 1329166-56-4 (E)-3-(2-acetyl-5-chlorophenyl)acrylic acid 
• 1294503-10-8 2-(2-bromo-4-chlorophenyl)-9-(4-bromophenyl)-7-phenyl-7H-pyrazolo[3,4-h][1,6]naphthyridine 
• 1374879-73-8 N'-[1-(2-bromo-4-chloro-phenyl)ethylidene]-2-cyanoacetohydrazide 
• 1086601-87-7 1-(2-bromo-4-chlorophenyl)ethanol 
• 1415130-73-2 N-(1-(2-bromo-4-chlorophenyl)ethyl)-4'-fluoro-[1,1'-biphenyl]-4-amine 

Relevant articles and documents

The intramolecular reaction of acetophenoneN-tosylhydrazone and vinyl: Br?nsted acid-promoted cationic cyclization toward polysubstituted indenes

In the presence of TsNHNH2, a Br?nsted acid-promoted intramolecular cyclization ofo-(1-arylvinyl) acetophenone derivatives was developed, leading to polysubstituted indenes with complexity and diversity in moderate to excellent yields. In sharp contrast with either the radical or carbene involved cyclization of aldehydicN-tosylhydrazone with vinyl, a cationic cyclization pathway was involved, whereN-tosylhydrazone served as an electrophile and alkylation reagent during this transformation.

Atmosphere-Controlled Palladium-Catalyzed Divergent Decarboxylative Cyclization of 2-Iodobiphenyls and α-Oxocarboxylic Acids

A novel palladium-catalyzed divergent decarboxylative cyclization of 2-iodobiphenyls and α-oxocarboxylic acids utilizing the atmosphere as a controlled switch is reported. Under the protection of a nitrogen atmosphere, tribenzotropones are synthesized by a [4 + 3] decarboxylative cyclization. Employing a palladium/O2 system enables a [4 + 2] decarboxylative cyclization to assemble triphenylenes. Notably, preliminary mechanistic studies indicate that the formation of triphenylenes involves a double decarboxylation.

PdII-Catalyzed Oxidative Tandem aza-Wacker/Heck Cyclization for the Construction of Fused 5,6-Bicyclic N,O-Heterocycles

A PdII-catalyzed oxidative tandem cyclization was developed for the construction of fused 5,6-bicyclic N, O-heterocycles. This reaction was enabled by the combined use of a 3-methylpyridine ligand and pentafluorobenzoic acid additive. A range of heterocyclic products with different substituents could be prepared in moderate to good yields via this methodology. Several transformations, including a scaled-up preparation of product 2 a, were also carried out showing the good applicability of our methodology.