825-94-5Relevant articles and documents
Asymmetric Synthesis of Silicon-Stereogenic Silanes by Copper-Catalyzed Desymmetrizing Protoboration of Vinylsilanes
Li, Yanfei,Wang, Ying,Xiong, Tao,Zhang, Ge,Zhang, Qian
supporting information, p. 11927 - 11931 (2020/05/22)
The catalytic asymmetric creation of silanes with silicon stereocenters is a long-sought but underdeveloped topic, and only a handful of examples have been reported. Moreover, the construction of chiral silanes containing (more than) two stereocenters is a more arduous task and remains unexploited. We herein report an unprecedented copper-catalyzed desymmetrizing protoboration of divinyl-substituted silanes with bis(pinacolato)diboron (B2pin2). This method enables the facile preparation of an array of enantiomerically enriched boronate-substituted organosilanes bearing contiguous silicon and carbon stereocenters with exclusive regioselectivity and generally excellent diastereo- and enantioselectivity.
Entecavir intermediate and its preparation method
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Paragraph 0380-0383; 0393; 0394; 0401, (2017/12/28)
The invention discloses an entecavir intermediate and a preparation method thereof. A provided preparation method for an entecavir intermediate compound 10 comprises the following steps: performing reducing reaction on an ester compound 11 in an organic solvent under the effect of a reducing agent, so as to obtain the compound 10. A provided preparation method for an entecavir intermediate compound 11 comprises the following steps: reacting a compound 12 with a hydroxyl protection reagent in an organic solvent in the presence of an acid to add a hydroxyl protection group, so as to obtain the compound 11. The preparation methods are cheap and easily available in raw materials, mild in reaction conditions, relatively high in product yield, good in atom economy, friendly to environment, and suitable for industrialized production.
Synthesis and characterization of new aromatic-group substituted silanes bearing tris (trimethylsilyl)methyl bulky groups
Tarassoli, Abbas,Asadi, Ashrafolmolouk
experimental part, p. 1463 - 1468 (2010/09/09)
Reaction of the Grignard reagent, p-ClC6H4MgCl, with SiCl4 in toluene gave (p-ClC6H4) 2SiCl2, which was treated with KHF2 to give (p-ClC6H4)2SiF2 (1). Reaction of the latter with [(Me3Si)3C]Li in THF leads to the preparation of [(Me3Si)3C](p-ClC6H4) 2SiF (2). Treatment of (2) with LiAlH4 gave [(Me 3Si)3C](p-ClC6H4)2SiH (3) and [(Me3Si)3C](p-ClC6H4)(C 6H5)SiH (4). [(Me3Si)3C](p-ClC 6H4)SiCl2 (5) was also prepared from the reaction of (p-ClC6H4)SiCl3 with [(Me 3Si)3C]Li in a similar manner. The new highly sterically hindered organosilicon reagents (2) to (5) have been fully characterized by IR, 1H and 13C NMR, and mass spectrometry as well as elemental analysis. Copyright Taylor & Francis Group, LLC.