82511-61-3

Basic information

• Product Name: 2-Methanesulfonyl-1H-pyrrole
• Synonyms: 2-Methanesulfonyl-1H-pyrrole
• CAS NO: 82511-61-3
• Molecular Formula: C₅H₇NO₂S
• Molecular Weight: 145.17958
• Mol File: 82511-61-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 379.7±24.0 °C(Predicted)
• Appearance: /
• Density: 1.325±0.06 g/cm3(Predicted)
• PKA: 14.00±0.50(Predicted)
• CAS DataBase Reference: 2-Methanesulfonyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methanesulfonyl-1H-pyrrole(82511-61-3)
• EPA Substance Registry System: 2-Methanesulfonyl-1H-pyrrole(82511-61-3)

Safety Data

• Hazardous Substances Data: 82511-61-3(Hazardous Substances Data)

Upstream product

• 53391-61-0 2-methylthiopyrrole 
• 156210-91-2 1-phenylsulfonyl-2-methylsulfonylpyrrole 
• 156210-90-1 1-phenylsulfonyl-2-methylthiopyrrole 

Downstream Products

• 156210-55-8 1-(2-bromobenzyl)-2-methylsufonylpyrrole 
• 156210-75-2 1-benzyl-2-methylsulfonylpyrrole 

Relevant articles and documents

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Oxidative radical cyclization to pyrroles under reducing conditions. Reductive desulfonylation of α-sulfonylpyrroles with tri-n-butyltin hydride

1-(2-Bromobenzyl)-2-alkanesulfonylpyrroles (1c, 1d) and 1-(4-bromobutyl)-2-methylsulfonylpyrrols (8) undergo oxidative radical cyclization with partial or complete reductive desulfonylation to the pyrrolizidine derivatives 5 and 9 by an AIBN initiated reaction with tri-n-butyltin hydride.These cyclizations are suggested to proceed via a pseudo SRN1 process involving radical addition to the α position of the pyrrole nucleus not bearing the sulfonyl group.Reductive removal of the alkylsulfonyl moiety is proposed to occur in a second process after completion of the oxidative radical cyclization.The site of the radical addition is supported by deuterium labelling studies.Consistent with the timing of the loss of the sulfonyl group is that 2-alkylsulfonylpyrroles 11 are reductively desulfonylated under the same conditions that effect the oxidative radical cyclizations.