82546-91-6Relevant articles and documents
Convenient and efficient synthesis of some novel fused thieno pyrimidines using gewald's reaction
Nirogi, Ramakrishna V.S.,Kambhampati, Sastri Rama,Kothmirkar, Prabhakar,Arepalli, Sobhanadri,Pamuleti, Narasimha Reddy G.,Shinde, Anil K.,Dubey
scheme or table, p. 2835 - 2851 (2011/09/12)
Several functionalized thienopyrimidines were synthesized by a facile synthetic method, which includes Gewald's reaction, and were characterized by spectral and analytical data. These functionalized thienopyrimidines were converted to various new chemical
Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp
Louise-May, Shirley,Yang, Wengang,Nie, Xingtie,Liu, Dongmei,Deshpande, Milind S.,Phadke, Avinash S.,Huang, Mingjun,Agarwal, Atul
, p. 3905 - 3909 (2008/02/07)
A novel 5,4-dialkyl substituted thiophene was discovered by in silico screening of the 3D polymerase crystal structure (1GX6) that demonstrated single digit micromolar HCV inhibition activity in the replicon assay and dose-dependent inhibition in the replicase complex assay. Subsequently, SAR was explored with a small set of dialkyl and tetrahydro-benzo thiophenes. Since these thiophenes inhibit synthesis of both, single- and double-stranded RNAs, their mechanism of action is distinct from other known HCV inhibitors.
Microwave-assisted gewald synthesis of 2-amimothio-phenes using functional ionic liquid as soluble support
Hu, Yi,Wei, Ping,Huang, He,Han, Shi-Qing,Ouyang, Ping-Kai
, p. 375 - 380 (2007/10/03)
A microwave-assisted liquid-phase Gewald synthesis of 2-aminothiophenes was developed using task-specific ionic liquid - [2-hydemim][BF4] as soluble support. This new synthetic method is simple and efficient, and the products are obtained in good to excellent yields with high purities, without the need for chromatographic purification.