82549-51-7

Basic information

• Product Name: (6R,7R)-7-Amino-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Synonyms: (6R,7R)-7-Amino-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;Parent nucleus of CefteraM(7-MTA);7-MTA;Cefteram mother nucleus;Parent nucleus of Cefteram
• CAS NO: 82549-51-7
• Molecular Formula: C10H12N6O3S
• Molecular Weight: 296.31
• EINECS: 1312995-182-4
• Mol File: 82549-51-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 679.073 °C at 760 mmHg
• Flash Point: 364.49 °C
• Appearance: /
• Density: 2.02±0.1 g/cm3(Predicted)
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• PKA: 2.54±0.50(Predicted)
• CAS DataBase Reference: (6R,7R)-7-Amino-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-7-Amino-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(82549-51-7)
• EPA Substance Registry System: (6R,7R)-7-Amino-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid(82549-51-7)

Safety Data

• Hazardous Substances Data: 82549-51-7(Hazardous Substances Data)

Usage

Uses

(6R,7R)-7-Amino-3-[(5-methyl-2H-tetrazol-2-yl)methyl]-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid s an impurity of Cefoperazone (C242900) and a second-generation cephalosporin antibiotic for antibacterial purposes.

Upstream product

• 4076-36-2 5-methyl-1,2,3,4-tetrazole 
• 957-68-6 7-Aminocephalosporanic acid 

Downstream Products

• 82547-58-8 cefteram 
• 82547-81-7 cefteram pivoxil 

Relevant articles and documents

Preparation method of cefteram pivoxil

The invention relates to a preparation method of cefteram pivoxil. The preparation method comprises following steps: taking 7-ACA and 5-methyltetrazole as starting raw materials, carrying out reactions in the presence of H2SO4 to generate 7-MTCA, protecting the amino groups of aminothiazol acetate, reacting aminothiazol acetate with 7-MTCA under the catalytic effect of AlMe3 to generate an intermediate (I); carrying out esterification reactions between the intermediate (I) and iodomethyl pivalate under the action of a phase transfer catalyst and an acid adsorbent, and removing the amino protection to obtain the target product (cefteram pivoxil). The reaction conditions are mild, the product purity and yield are high, and the technology is stable, is easy for amplification, and is suitablefor industrial production.