82558-50-7 Usage
Uses
Different sources of media describe the Uses of 82558-50-7 differently. You can refer to the following data:
1. Isoxaben is used primarily for preemergence control of
annual broadleaf weeds. Isoxaben is usually applied to
soil either with light incorporation or before application
of water (at least 0.5 in) within 3 weeks. As is the case
with DCB, it is most effective on weed seedlings before
emergence.
2. Isoxaben is a herbicide residue in tea and other plants. A cellulose biosynthesis inhibitor in plants.
Definition
ChEBI: A benzamide obtained by formal condensation of the carboxy group of 2,6-dimethoxybenzoic acid and the amino group of 3-(3-methylpentan-3-yl)-1,2-oxazol-5-amine.
Pharmacology
Although isoxaben is readily absorbed through the
root system, foliar absorption and translocation is poor.
Reduced root absorption may be partly responsible for
the tolerance of some dicot species to isoxaben, although
differences in the site of action appears to be the major
contributing factor in tolerance (15).Up to 50% of absorbed
isoxaben is metabolized within 6 days following root application
(16). Differences in metabolism cannot explain
the selectivity of isoxaben between tolerant and susceptible
species (17,18). Metabolism of isoxaben involves
hydroxylation of the propyl side group and glucosylation.
2,6-dimethoxybenzamide is found as a minor metabolite
(19). Isoxaben prevents the germination and growth of
seedlings before emergence, by inhibiting cell division.
The primary mode of action of isoxaben is inhibition of
cellulose biosynthesis, although the exact mechanism is
unclear. Isoxaben has been shown to specifically inhibit
the incorporation of glucose into the acid-insoluble fraction
(presumed to be cellulose) of the cell walls of Arabidopsis
thaliana (20) and soybean cell suspension cultures (21).
This herbicide also disrupts cell plate formation in root
tips (22) and tobacco suspension cells (23). Isoxaben affects
a different site of action compared with DCB, as it inhibits
cytokinesis at an earlier stage in which callose is deposited
at the developing cell plate (23). There are no known cases
of resistance to this herbicide.
Metabolism
Isoxaben is adsorbed strongly to soil and therefore has
very limited mobility. Volatilization and photodegradation
of isoxaben is negligible when applied to soil. Isoxaben is
mainly degraded by soil organisms and has an average
half-life of 1 to 2 months in the field, providing an average
of 5 to 6 months of weed control at normal rates of
application (19).
Toxicity evaluation
Isoxaben is classified as a general use herbicide. Although
it is noncarcinogenic, it is classified as a Class C oncogen
based on increased incidence of benign liver tumors in
one experimental system tested (mice). It is relatively
nontoxic to mammals with an oral LD50 of >10 g/kg in
rats and mice (19).
Isoxaben is nonflammable and noncorrosive. It is stable
under normal conditions, but it is degraded by ultraviolet
light in aqueous solution and decomposes at 220 ?C (19).
Check Digit Verification of cas no
The CAS Registry Mumber 82558-50-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,5,5 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 82558-50:
(7*8)+(6*2)+(5*5)+(4*5)+(3*8)+(2*5)+(1*0)=147
147 % 10 = 7
So 82558-50-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H24N2O4/c1-6-18(3,7-2)14-11-15(24-20-14)19-17(21)16-12(22-4)9-8-10-13(16)23-5/h8-11H,6-7H2,1-5H3,(H,19,21)
82558-50-7Relevant articles and documents
PLANTS HAVING INCREASED TOLERANCE TO HERBICIDES
-
, (2013/03/26)
The present invention refers to a method for controlling undesired vegetation at a plant cultivation site. The method comprises the steps of providing, at said site, a plant that comprises at least one nucleic acid comprising a nucleotide sequence encoding a wild-type hydroxyphenyl pyruvate dioxygenase or a mutated hydroxyphenyl pyruvate dioxygenase (mut-HPPD) which is resistant or tolerant to a coumarone-derivative herbicide and/or a nucleotide sequence encoding a wild-type homogentisate solanesyl transferase or a mutated homogentisate solanesyl tranferase (mut-HST) which is resistant or tolerant to a coumarone derivative herbicide, and then applying an effective amount of said herbicide to said plant cultivation site. The invention further refers to plants comprising mut-HPPD and to methods of obtaining such plants.
Herbicidal mixtures having a synergistic effect
-
, (2008/06/13)
PCT No. PCT/EP96/03996 Sec. 371 Date Feb. 17, 1998 Sec. 102(e) Date Feb. 17, 1998 PCT Filed Sep. 12, 1996 PCT Pub. No. WO97/10714 PCT Pub. Date Mar. 27, 1997A composition comprising at least one sulfonylurea of the formula I wherein R1 is substituted alkyl; halogen; a group ER6 (E=O, S or NR7); COOR8; NO2; S(O)oR9; SO2NR10R11; or CONR10R11; R2 is hydrogen, alkyl, alkenyl, alkynyl, halogen, alkoxy, haloalkoxy, haloalkyl, alkylsulfonyl, nitro, cyano or alkylthio; R3 is F, CF3, CF2Cl, CF2H, OCF3, OCF2Cl, or, if R1 is CO2CH3 and R2 is simultaneously fluorine, R3 is Cl, or, if R1 is CH2CF3 or CF2CF3, R3 is methyl, or, if R4 is OCF3 or OCF2Cl, R3 is OCF2H or OCF2Br; R4 is alkoxy, alkyl, alkylthio, alkylamino, dialkylamino, halogen, haloalkyl or haloalkoxy; and R5 is hydrogen, alkoxy or alkyl; or an enviromentally compatible salt of I, and an aryloxyalkanoic acid selected from the group consisting of 2,4-D, 2,4-DB, clomeprop, dichlorprop, dichlorprop-P, dichlorprop-P (2,4-DP-P), fenoprop (2,4,5-TP), fluoroxypyr, MCPA, MCPB, mecoprop, mecoprop-P, napropamide, napropanilide, triclopyr, and an enviromentally compatible salt thereof exhibits a synergistic herbicidal effect.
Benzamides, compositions and agricultural method
-
, (2008/06/13)
N-Aryl benzamides wherein the aryl group is a nitrogen containing heterocycle are useful as selective herbicidal agents. Compositions containing the novel benzamides and a herbicidal method of selective weed control are disclosed.
