82575-10-8

Basic information

• Product Name: (+/-)-trans-4-Ethyl-4-phenyl-2-oxetanone
• CAS NO: 82575-10-8
• Molecular Weight: 176.215
• Mol File: 82575-10-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (+/-)-trans-4-Ethyl-4-phenyl-2-oxetanone(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)-trans-4-Ethyl-4-phenyl-2-oxetanone(82575-10-8)
• EPA Substance Registry System: (+/-)-trans-4-Ethyl-4-phenyl-2-oxetanone(82575-10-8)

Safety Data

• Hazardous Substances Data: 82575-10-8(Hazardous Substances Data)

Upstream product

• 4346-18-3 phenyl butanoate 
• 100-52-7 benzaldehyde 
• 14367-04-5 threo-2-Ethyl-3-hydroxy-3-phenylpropionsaeure 
• 14367-04-5 erythro-2-Ethyl-3-hydroxy-3-phenylpropionsaeure 

Downstream Products

• 1560-09-4 (Z)-but-1-en-1-ylbenzene 

Relevant articles and documents

Synthesis of β-Lactones via a Spontaneous Intramolecular Cyclization of O-Lithiated Phenyl β-Hydroxyalkanoates Obtained by Aldolization of Ketones or Aldehydes with Lithium Enolates of Phenyl Esters

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Dehydrative Decarboxylation of 2,3-Disubstituted 3-Hydroxycarboxylic Acids with Dimethylformamide Acetals - Mechanistic Studies and Preparative Applicability

Dimethylformamide dimethylacetal (2a) converts the threo-3-hydroxycarboxylic acids 4 smoothly into the (E)/(Z)-olefins 7/6 only if R2 is an aryl or vinyl substituent.Althougt the reaction exhibits a distinct (E)-selectivity it cannot be considered as a stereo-controlled olefin synthesis.If R2 is alkyl, 2a generates the methyl esters 10 from 4.The erythro-acids 5 react with 2a to give 43 - 95percent of >98percent sterically pure 7.As the key tranformation on the multistep way from 4/5 to 6/7 the fragmentation of the zwitterionic intermediate 11/20 is postulated.