82578-49-2

Basic information

• Product Name: methyl 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoate
• Synonyms: methyl 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoate
• CAS NO: 82578-49-2
• Molecular Weight: 401.385
• Mol File: 82578-49-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoate(82578-49-2)
• EPA Substance Registry System: methyl 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoate(82578-49-2)

Safety Data

• Hazardous Substances Data: 82578-49-2(Hazardous Substances Data)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 1019854-31-9 methyl 5-phenylmethoxy-2[((trifluoromethyl)sulfonyl)oxy]benzoate 
• 98-16-8 3-trifluoromethylaniline 
• 56961-30-9 2-chloro-5-hydroxybenzoic acid 
• 39062-64-1 5-(benzyloxy)-2-chlorobenzoic acid 
• 89-54-3 2-chloro-5-aminobenzoic acid 
• 39062-65-2 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 39062-65-2 5-phenylmethoxy-2-[(3-trifluoromethylphenyl)amino]benzoic acid 
• 76874-96-9 5-hydroxy-etofenamate 
• 82578-50-5 5-Benzyloxy-2-(3-trifluoromethyl-phenylamino)-benzoic acid 2-(2-hydroxy-ethoxy)-ethyl ester 

Relevant articles and documents

Conception of myeloperoxidase inhibitors derived from flufenamic acid by computational docking and structure modification

The development of myeloperoxidase (MPO) inhibitors has been conducted using flufenamic acid as a lead compound. Computational docking of the drug and its analogs in the MPO active site was first attempted. Several molecules were then synthesized and assessed using three procedures for the measurement of their inhibiting activity: (i) the taurine assay, (ii) the accumulation of compound II, and (iii) the LDL oxidation by ELISA. Most of the synthesized molecules had an activity in the same range as flufenamic acid but none of them were able to inhibit the MPO-dependent LDL oxidation. The experiments however gave some useful indications for a rational conception of MPO inhibitors.