82584-14-3

Basic information

• Product Name: 1-(IsochroMan-1-yl)propan-2-one
• Synonyms: 1-(IsochroMan-1-yl)propan-2-one
• CAS NO: 82584-14-3
• Molecular Formula: C₁₂H₁₄O₂
• Molecular Weight: 190.23836
• Mol File: 82584-14-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 105-110 °C(Press: 0.02 Torr)
• Appearance: /
• Density: 1.065±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(IsochroMan-1-yl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(IsochroMan-1-yl)propan-2-one(82584-14-3)
• EPA Substance Registry System: 1-(IsochroMan-1-yl)propan-2-one(82584-14-3)

Safety Data

• Hazardous Substances Data: 82584-14-3(Hazardous Substances Data)

Usage

General Description

1-(IsochroMan-1-yl)propan-2-one is a synthetic chemical compound with the molecular formula C10H12O. It is a ketone derivative that belongs to the family of isochroman compounds. This chemical is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is also utilized in the manufacturing of fragrances, dyes, and flavoring agents. 1-(IsochroMan-1-yl)propan-2-one has potential applications in research and development for the pharmaceutical industry due to its unique structure and properties. However, it is important to handle this chemical with care, as it may pose health and safety hazards if not used properly.

Upstream product

• 75802-22-1 1-ethoxyisochromane 
• 67-64-1 acetone 
• 34818-50-3 isochroman-1-yl acetate 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 82584-07-4 rac-3-(isochroman-1'-yl)acetylacetone 
• 493-05-0 isochromane 
• 541-50-4 2-acetoacetic acid 

Downstream Products

• 104773-58-2 N-phenyl-2-(isochroman-1-yl)-1-methylethylamine 
• 117368-61-3 N-(3-phenylpropyl)-2-(isochroman-1-yl)-1-methylethylamine 
• 104773-51-5 N-benzyl-2-(isochroman-1-yl)-1-methylethylamine 
• 104797-98-0 N-phenethyl-2-(isochroman-1-yl)-1-methylethylamine 
• 134480-71-0 1-(4-hydroxyphenyl)-2-[2-(isochroman-1-yl)-1-methylethylamino]ethanol 
• 134480-92-5 1-[2-(Isochroman-1-yl)-1-methylethylamino]-3-phenyl-2-propanol 

Relevant articles and documents

Structurally diverse α-substituted benzopyran synthesis through a practical metal-free C(sp3)-H functionalization

A trityl ion-mediated practical C-H functionalization of a variety of benzopyrans with a wide range of nucleophiles (organoboranes and C-H molecules) at ambient temperature has been disclosed. The metal-free reaction has an excellent functional group tole

Catalyzed selective direct α- And γ-alkylation of aldehydes with cyclic benzyl ethers by using T+BF4- in the presence of an inexpensive organic acid or anhydride

The cross dehydrogenative coupling (CDC) of cyclic benzyl ethers with aliphatic and α,β-unsaturated aldehydes has been developed. The mild reaction conditions, in which an N-oxoammonium salt derived from TEMPO (2,2,6,6-tetramethyl-1-piperidinoxyl) is employed as the oxidant in combination with a Cu catalyst, allow the use of relatively redox-unstable aldehydes under oxidative CDC conditions. The addition of a catalytic amount of trifluoroacetic acid (TFA) or Ac2O facilitates the reaction and increases the efficiency and selectivity. In contrast to the expected α-alkylation obtained with aliphatic aldehydes, α,β-unsaturated aldehydes led preferentially to the more challenging γ-alkylated products. The utility of the developed methodology was demonstrated by the synthesis of isochromane-derived bioactive compounds, such as the dopamine antagonist sonepiprazole.

Synthesis and antiulcer activity of (isochroman-1-yl)alkylamines. I

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