82585-38-4 Usage
Derivative
Acetophenone oxime
Substituent Group
Contains an amino and a methoxy group attached to the phenyl ring
Common Uses
Organic synthesis
Pharmaceutical research
Potential Applications
Development of new drugs
Formation of stable complexes with various metal ions
Properties
Anti-inflammatory: Exhibits anti-inflammatory properties
Anti-cancer: Exhibits anti-cancer properties
Reactivity: Oxime moiety allows for nucleophilic addition reactions with aldehydes and ketones
Specific Content
Organic Synthesis: Used in the synthesis of various organic compounds
Metal Complexation: Forms stable complexes with metal ions
Biological Activity: Shows potential pharmacological effects, including anti-inflammatory and anti-cancer activities
Check Digit Verification of cas no
The CAS Registry Mumber 82585-38-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,5,8 and 5 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 82585-38:
(7*8)+(6*2)+(5*5)+(4*8)+(3*5)+(2*3)+(1*8)=154
154 % 10 = 4
So 82585-38-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H12N2O2/c1-13-8-4-2-3-7(5-8)9(6-10)11-12/h2-5,12H,6,10H2,1H3/b11-9+
82585-38-4Relevant articles and documents
New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)
Temple, Carroll,Wheeler, Glynn P.,Elliott, Robert D.,Rose, Jerry D.,Kussner, Conrad L.,et al.
, p. 1045 - 1050 (2007/10/02)
Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.
