82587-72-2

Basic information

• Product Name: 3-(4-Methylbenzoyl)-2H-chroMen-2-one
• Synonyms: 3-(4-Methylbenzoyl)-2H-chroMen-2-one
• CAS NO: 82587-72-2
• Molecular Formula: C₁₇H₁₂O₃
• Molecular Weight: 264.27538
• Mol File: 82587-72-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Methylbenzoyl)-2H-chroMen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methylbenzoyl)-2H-chroMen-2-one(82587-72-2)
• EPA Substance Registry System: 3-(4-Methylbenzoyl)-2H-chroMen-2-one(82587-72-2)

Safety Data

• Hazardous Substances Data: 82587-72-2(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 55991-68-9 5-(p-tolyl)-2,3-dihydro-2,3-furandione 
• 89-95-2 2-methyl-benzyl alcohol 
• 41467-27-0 3,3-bis(methylthio)-1-(p-tolyl)prop-2-en-1-one 
• 37510-36-4 methyl 3-hydroxy-3-(p-methylphenyl)prop-2-enedithioate 
• 122-00-9 para-methylacetophenone 
• 27835-00-3 ethyl (4-methylbenzoyl)acetate 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 91-64-5 coumarin 
• 104-87-0 4-methyl-benzaldehyde 
• 589-18-4 4-Methylbenzyl alcohol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 531-81-7 2-oxo-2H-chromene-3-carboxylic acid 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1416572-92-3 (1S,10bS)-1-ethyl-1-phenyl-4-p-tolyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 
• 1416573-11-9 (1R,10bR)-1-ethyl-1-phenyl-4-p-tolyl-1,10b-dihydropyrano[3,4-c]chromene-2,5-dione 
• 1401353-72-7 (E)-ethyl 2-(5-oxo-4-(p-tolyl)-1,10b-dihydro-5H-pyrano[3,4-c]chromen-2-ylidene)acetate 
• 1401353-82-9 3a-(4-methylbenzoyl)-1-(ethoxycarbonyl)-3a,9b-dihydro-3H-cyclopenta[c]chromen-4-one 

Relevant articles and documents

A Regioselective Approach to C3-Aroylcoumarins via Cobalt-Catalyzed C(sp 2)-H Activation Carbonylation of Coumarins

A new cobalt-catalyzed C-H bond activation of coumarins with aryl halides or pseudohalides and carbon monoxide insertion to give various 3-aroylcoumarin derivatives is described. It is the first time that CO as C1 feedstock is used as the coupling partners in cobalt-catalyzed regioselective coumarin C-H functionalization reactions. Upon activation with manganese powder, the Co catalyzes the C-H bond activation carbonylation reactions of aryl iodides, bromides, and even triflates under mild conditions, providing the regioselective aroylated products in moderate to good yields.

A Regioselective Metal-Free Construction of 3-Aroyl Coumarins by Csp2-H Functionalization

A successive metal-free TBHP-mediated regioselective C-H functionalization of coumarins toward expedient synthesis of 3-aroyl coumarins is unveiled. The ongoing method conducted through the reaction of either coumarins or coumarin-3-carboxylic acids with

Regioselective Coupling Reactions of Coumarins with Aldehydes or Di-tert-butyl Peroxide (DTBP) through a C(sp2)-H Functionalization Process

Coumarin derivatives are highly valuable compounds in drug discovery. Herein, we have developed two new coupling reactions that involve coumarins and either aldehydes or di-tert-butyl peroxide (DTBP) in the presence of inexpensive copper or iron catalysts. Both of these reactions proceed through a C(sp2)-H functionalization process to regioselectivity generate keto- or methyl-substituted coumarin derivatives in moderate to good yields These coupling reactions will enrich current coumarin chemistry.