826-72-2

Basic information

• Product Name: 1-Methyl-3,4-dihydro-1H-quinolin-2-one
• Synonyms: 1-Methyl-3,4-dihydro-1H-quinolin-2-one;1-Methyl-3,4-dihydroquinolin-2(1H)-one
• CAS NO: 826-72-2
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.203
• Mol File: 826-72-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 360.8°C at 760 mmHg
• Flash Point: 178.1°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 2.17E-05mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 1-Methyl-3,4-dihydro-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3,4-dihydro-1H-quinolin-2-one(826-72-2)
• EPA Substance Registry System: 1-Methyl-3,4-dihydro-1H-quinolin-2-one(826-72-2)

Safety Data

• Hazardous Substances Data: 826-72-2(Hazardous Substances Data)

Usage

General Description

1-Methyl-3,4-dihydro-1H-quinolin-2-one is a chemical compound with the molecular formula C10H11NO. It is a heterocyclic compound with a bicyclic structure and a quinoline backbone. 1-Methyl-3,4-dihydro-1H-quinolin-2-one is used in the field of organic chemistry and pharmaceutical research as a building block for the synthesis of various drugs and bioactive molecules. Its unique structure and reactivity make it a valuable intermediate in the production of pharmaceuticals and agrochemicals. Additionally, 1-Methyl-3,4-dihydro-1H-quinolin-2-one has been studied for its potential biological activities and pharmacological properties, making it an important target for medicinal chemistry research.

InChI:InChI=1/C10H11NO/c1-11-9-5-3-2-4-8(9)6-7-10(11)12/h2-5H,6-7H2,1H3

Upstream product

• 78-81-9 isobutylamine 
• 111083-42-2 2-<3,3-bis(ethoxycarbonyl)propyl>pyridine methiodide 
• 102804-47-7 N-(2-bromophenyl)-N-methyl-2-propenamide 
• 111097-88-2 2-<3,3-bis(ethoxycarbonyl)propyl>pyridine ethiodide 
• 74-89-5 methylamine 
• 100-46-9 benzylamine 

Downstream Products

• 72503-24-3 3-(2-methylamino-phenyl)-propionic acid 
• 72502-98-8 3-[2-(N-methyl-benzamido)-phenyl]-propionic acid 
• 85312-26-1 N-Methyl-3,4-dihydro-chinolin-thion-(2) 
• 491-34-9 N-methyl-1,2,3,4-tetrahydroquinoline 
• 240798-91-8 2-(2-methylaminophenyl)propan-1-ol 
• 871269-42-0 (Z)-3-(1-acetylamino-1-phenylmethylene)-1-methyl-3,4-dihydroquinolin-2(1H)-one 
• 871269-43-1 (Z)-3-[1-acetylamino-1-(2-fluorophenyl)methylene]-1-methyl-3,4-dihydroquinolin-2(1H)-one 
• 871269-45-3 (Z)-3-(1-acetylamino-2-cyclohexylmethylene)-1-methyl-3,4-dihydroquinolin-2(1H)-one 

Relevant articles and documents

Electrocatalytic Coupling of Aryl Halides with (1,2-Bis(di-2-propylphosphino)benzene)nickel(0)

Dibromo- and dichloro(1,2-bis(di-2-propylphosphino)benzene)nickel(II) is compared with tetrakis(triphenylphosphino)nickel(II) as an electrocatalyst for the reductive coupling of aryl halides.In many of the reactions examined, dehalogenation of the substrate predominated over coupling; however, preparative yields of biphenyls as high as 96percent can be obtained with aryl chlorides and 2 mol percent of the title catalyst in polar, coordinating solvents.Experimental factors governing the efficiency of these reactions are discussed, and possible mechanisms for coupling and catalyst deactivation are considered.Much better selectivity for aryl chlorides is attained in electroreductive couplings catalyzed by the title compound, whereas electrocatalysis with (Ph3P)4NiCl2 allows for selective intra- and intermolecular coupling at aryl bromide and vinyl chloride sites.Modest yields of cyclization products can be attained with either electrocatalyst in the presence of appropriately functionalized aryl or vinyl halides.