826-85-7

Basic information

• Product Name: 5-AMINO-1-PHENYLPYRAZOLE
• Synonyms: 5-AMINO-1-PHENYLPYRAZOLE;BUTTPARK 23\09-46;1-phenyl-1h-pyrazol-5-amin;5-amino-1-phenyl-pyrazol;1-phenylpyrazol-5-ylamine;Aminophenylpyrazole;5-AMINO-1-PHENYLPYRAZOLE 98+% T;1-Phenyl-1H-pyrazol-5-amine
• CAS NO: 826-85-7
• Molecular Formula: C₉H₉N₃
• Molecular Weight: 159.19
• EINECS: 212-563-1
• Mol File: 826-85-7.mol
• Article Data: 21

Chemical Properties

• Melting Point: 51°C
• Boiling Point: 323.2 °C at 760 mmHg
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.2 g/cm³
• Vapor Pressure: 0.000267mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 3.17±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-1-PHENYLPYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-PHENYLPYRAZOLE(826-85-7)
• EPA Substance Registry System: 5-AMINO-1-PHENYLPYRAZOLE(826-85-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: UQ6108000
• Hazardous Substances Data: 826-85-7(Hazardous Substances Data)

Usage

Uses

5-Amino-1-phenylpyrazole is a reagent that is used in the synthesis of sulfaphenazole(S689020) derivatives as inhibitors and tools for comparing active sites of human liver cytochromes P 450 2C subfamily.

InChI:InChI=1/C9H9N3/c10-9-6-7-11-12(9)8-4-2-1-3-5-8/h1-7H,10H2

Upstream product

• 51649-80-0 5-amino-1-phenyl-1H-pyrazole-4-carboxylic acid 
• 16078-71-0 ethyl 5-amino-1-phenyl-1H-pyrazole-4-carboxylate 
• 26955-79-3 3-(N'-phenyl-hydrazino)-propionitrile 
• 5334-43-0 5-Amino-4-cyano-1-phenylpyrazole 
• 79442-79-8 2-Methoxy-N-(2-phenyl-2H-pyrazol-3-yl)-benzamide 
• 140367-36-8 (5-amino-1-phenylpyrazol-4-yl)triphenylphosphonium iodide 
• 25112-05-4 cyanoacetaldehyde phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 60838-50-8 3-methoxy-2-propenenitrile 
• 591-50-4 iodobenzene 
• 1820-80-0 3-aminopyrazole 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 124-41-4 sodium methylate 
• 59-88-1 phenylhydrazine hydrochloride 

Downstream Products

• 855-91-4 N₄-Acetylsulfaphenazole 
• 77746-64-6 1-Phenyl-5-{[1-piperidin-1-yl-meth-(E)-ylidene]-amino}-1H-pyrazole-4-carbaldehyde 
• 116855-22-2 2-[(2-Phenyl-2H-pyrazol-3-ylamino)-methylene]-malononitrile 
• 20208-81-5 1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 59026-68-5 6-methyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 98157-50-7 5-Nitro-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 75303-33-2 6-Ethoxy-4-methyl-2-phenyl-pyrazolo<3,4-b>pyridin 
• 2609-70-3 (Z)-3-(2-Phenyl-2H-pyrazol-3-ylamino)-but-2-enoic acid ethyl ester 
• 17436-81-6 6,7-Dihydro-4-methyl-6-oxo-1-phenyl-pyrazolo<3,4-b>pyridin 
• 77746-89-5 N-(2-Phenyl-2H-pyrazol-3-yl)-benzamide 
• 77746-71-5 N,N-Dimethyl-N'-(2-phenyl-2H-pyrazol-3-yl)-formamidine 
• 77746-55-5 N'-(4-Formyl-2-phenyl-2H-pyrazol-3-yl)-N,N-dimethyl-formamidine; hydrochloride 
• 2868-42-0 4,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine 
• 93734-41-9 (E)-ethyl 2-cyano-3-((1-phenyl-1H-pyrazol-5-yl)amino)acrylate 

Relevant articles and documents

Cu(OAc)2-porphyrins as an efficient catalytic system for base-free, nature mimicking Chan–Lam coupling in water

The use of porphyrins as ligands in organic synthesis reveals the natural process, because these are the constituent motifs of catalysts in many bio-organic reactions. This article presents the synthesis of two N-pincer tetradentate porphyrins; tetrasodium meso-tetra(p-sulfonatophenyl)phorphyrin (H2TSTpSPP) and meso-tetra(m-carboxyphenyl)porphyrin (H2TmCPP), and study on their aptness for Cu-catalyzed C–N coupling reactions of arylboronic acids and amines (Chan–Lam coupling reaction) in water under external base free conditions. The porphyrins and Chan–Lam coupling products were well characterized by their spectral analysis. The high product yields, application of nature-inspired conditions, large extent of substrates, ease of making and handling the ligands, avoidance of base, and use of water as reaction media are the attractive attributes of this finding.

COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY

This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt

A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.