82652-17-3

Basic information

• Product Name: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE
• Synonyms: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE
• CAS NO: 82652-17-3
• Molecular Formula: C9H9FO3S
• Molecular Weight: 216.23
• Mol File: 82652-17-3.mol
• Article Data: 13

Chemical Properties

• Melting Point: 111-113°C
• Appearance: /
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE(82652-17-3)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)-2-(METHYLSULFONYL)-1-ETHANONE(82652-17-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 82652-17-3(Hazardous Substances Data)

Usage

Description

1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone is a chemical compound characterized by its molecular formula C10H11FO2S. It is a ketone derivative featuring a fluoro-substituted phenyl group and a methylsulfonyl group attached to the ethanone moiety. 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone holds potential for applications in organic synthesis and pharmaceutical research, although its properties and uses require further investigation and analysis. Careful handling is advised due to possible health and environmental risks.

Uses

Used in Organic Synthesis:
1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone is used as an intermediate in the synthesis of various organic compounds, leveraging its unique structural features to facilitate the creation of complex molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1-(4-fluorophenyl)-2-(methylsulfonyl)-1-ethanone is used as a key component in the development of new drugs, potentially contributing to the discovery of novel therapeutic agents.

Upstream product

• 58518-77-7 ((1-(4-fluorophenyl)vinyl)oxy)trimethylsilane 
• 124-63-0 methanesulfonyl chloride 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 20277-69-4 sodium methansulfinate 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 405-99-2 para-fluorostyrene 
• 67-68-5 dimethyl sulfoxide 
• 122831-40-7 1-(4-fluorophenyl)-2-(methylthio)ethan-1-one 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 67-71-0 dimethylsulfone 
• 403-33-8 methyl 4-flurobenzoate 
• 766-98-3 1-ethynyl-4-fluorobenzene 

Downstream Products

• 1363808-19-8 5-[(2,6-diethyl-4-methylphenyl)carbonyl]-3-(4-fluorophenyl)-1-methyl-4-methylsulfonyl-1H-pyrazole 
• 1363808-15-4 4-(2,6-diethyl-4-methylphenyl)-6-(4-fluorophenyl)-2-methyl-5-methylsulfonyl-2,3-dihydro-3-pyridazinone 

Relevant articles and documents

Copper-catalyzed aerobic oxidative cross-coupling reactions of vinylarenes with sulfinate salts: A direct approach to β-ketosulfones

A copper-catalyzed aerobic oxidative cross-coupling reactions for the synthesis of β-ketosulfones via formation of a C[sbnd]S bond has been demonstrated. Promoted by the crucial copper catalyst, perfect selectivity and good to excellent yields could be achieved. This method, including inexpensive copper catalyst, wide functional group tolerance, and open air conditions, make it very attractive and practical. More importantly, it also provides a versatile tool for the construction of β-ketosulfones from basic starting materials under mild conditions.

Visible-light-promoted aerobic oxidative synthesis of β-ketosulfones under photocatalyst-free conditions

A simple and convenient visible-light-mediated method has been developed for the construction of β-ketosulfones via aerobic oxidative difunctionalization of alkynes with arylazo sulfones and dioxygen in air under photocatalyst-free conditions. The present photochemical methodology provides a facile and attractive protocol to construct a series of β-ketosulfones in moderate to good yields.

Preparation method of beta-carbonyl sulfone compound promoted by visible light

The invention discloses a preparation method of a beta-carbonyl sulfone compound promoted by visible light. The preparation method includes the following steps that olefin and aryl-sulphonazo are mixed with an organic solvent and water, and then a reaction is conducted for 16-24 hours at room temperature under visible illumination; and after the reaction, ethyl acetate is used for extracting reaction liquid, and the beta-carbonyl sulfone compound is obtained after concentration and column chromatography isolation of an extract. According to the method, clean light energy is used as reaction energy, oxygen in air is used as an oxidant and an oxygen source, the beta-carbonyl sulfone compound is effectively synthesized at the room temperature, the method does not require any photocatalyst orequivalent inorganic oxidant, and has the advantages of easy and convenient operation, low energy consumption, high reaction safety, environmental friendliness and the like.