82730-72-1

Basic information

• Product Name: R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN&
• Synonyms: R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN&;R(+)-7-HYDROXY-DPAT HYDROBROMIDE >98% (R (+)-7-HYDROXY-DIPRO;R(+)-7-Hydroxy(dipropylamino)tetralin hydrobromide, R(+)-2-Dipropylamino-7-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide;R(+)-7-Hydroxy(dipropylamino)tetralin hydrobromide
• CAS NO: 82730-72-1
• Molecular Formula: C16H25NO
• Molecular Weight: 247.3758
• Mol File: 82730-72-1.mol
• Article Data: 2

Chemical Properties

• Appearance: white/solid
• Solubility: H2O: >100 mg/mL
• CAS DataBase Reference: R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN&(CAS DataBase Reference)
• NIST Chemistry Reference: R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN&(82730-72-1)
• EPA Substance Registry System: R(+)-7-HYDROXY-2-DIPROPYLAMINO TETRALIN&(82730-72-1)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 82730-72-1(Hazardous Substances Data)

Upstream product

• 158111-39-8 (R)-7-OMe-DPAT 
• 93503-15-2 N-((R)-7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-N-propyl-propionamide 
• 93503-08-3 (R)-7-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride 

Relevant articles and documents

Affinity for dopamine D2, D3, and D4 receptors of 2-aminotetralins. Relevance of D2 agonist binding for determination of receptor subtype selectivity.

A series of 2-aminotetralins, substituted with a methoxy or a hydroxy group on the 5- or 7-position, and with varying N-alkyl or N-arylalkyl substituents, were prepared and evaluated in binding assays for human dopamine (DA) D2, D3, and D4 receptors. Some members of this series were prepared in former studies, but were never tested in vitro with single receptor subtypes, and these were examined again. None of the tested 2-aminotetralins showed high affinity for the dopamine D4 receptor. However, a number of the 2-aminotetralins showed high affinity for both the D2 and the D3 DA receptors, as exemplified by compounds 11-15 and 21-26, while some had a reasonable selectivity for the DA D3 receptors. The affinities of the 2-aminotetralins for the D21, receptor depended on the type of radioligand (agonist or antagonist) used. The agonist affinity data, obtained by using the agonist ligand [3H]N-0437, are thought to be more relevant for calculating DA receptor subtype selectivity.