827325-51-9Relevant articles and documents
Total synthesis of ingenol
Nickel, Andrew,Maruyama, Toru,Tang, Haifeng,Murphy, Prescott D.,Greene, Blake,Yusuff, Naeem,Wood, John L.
, p. 16300 - 16301 (2007/10/03)
A total synthesis of the biologically important diterpene ingenol has been completed. Ring-closing olefin metathesis was used to construct the strained "inside-outside" tetracyclic skeleton, and a series of diastereoselective reactions were employed to complete the synthesis. Another naturally occurring ingenane, 20-deoxyingenol, has also been prepared. Copyright
