827332-78-5

Basic information

• Product Name: 3-(2-Bromophenyl)-5-phenyl-1,2,4-oxadiazole
• Synonyms: 3-(2-Bromophenyl)-5-phenyl-1,2,4-oxadiazole
• CAS NO: 827332-78-5
• Molecular Formula: C₁₄H₉BrN₂O
• Molecular Weight: 301.14
• Mol File: 827332-78-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 428.8 °C at 760 mmHg
• Flash Point: 213.1 °C
• Appearance: /
• Density: 1.465 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-Bromophenyl)-5-phenyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Bromophenyl)-5-phenyl-1,2,4-oxadiazole(827332-78-5)
• EPA Substance Registry System: 3-(2-Bromophenyl)-5-phenyl-1,2,4-oxadiazole(827332-78-5)

Safety Data

• Hazardous Substances Data: 827332-78-5(Hazardous Substances Data)

Usage

General Description

3-(2-Bromophenyl)-5-phenyl-1,2,4-oxadiazole is a chemical compound with the molecular formula C13H8BrN3O. It belongs to the class of oxadiazoles, which are organic compounds containing a five-membered heterocyclic ring with an oxygen and two nitrogen atoms. This specific compound is characterized by a 1,2,4-oxadiazole ring structure with a phenyl and a bromophenyl group attached to it. It has potential applications in the field of medicinal chemistry, specifically as a potential scaffold for the development of new drugs due to its diverse biological activities. Additionally, oxadiazole derivatives have been studied for their potential antimicrobial, anti-tuberculosis, and antitumor properties.

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Relevant articles and documents

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Orthogonal aerobic conversion of N-benzyl amidoximes to 1,2,4-oxadiazoles or quinazolinones

Concise synthesis of 1,2,4-oxadiazoles was achieved by heating N-benzyl amidoximes with K3PO4 in DMF at 60°C under an O 2 atmosphere via benzylic C-H oxygenation. On the other hand, aerobic treatment of N-benzyl amidoximes