82746-43-8Relevant articles and documents
Novel indolizine derivatives with unprecedented inhibitory activity on human farnesyltransferase
Dumea, Carmen,Belei, Dalila,Ghinet, Alina,Dubois, Jolle,Farce, Amaury,Bcu, Elena
, p. 5777 - 5781 (2014)
The rational structural modification of new substituted indolizin-3-yl(phenyl)methanones 1a-i, 2a-i and 3a-i has greatly improved human farnesyltransferase inhibition. The para-bromophenyl analog 2f bearing an ester unit on the indolizine ring demonstrates the highest inhibition potential, with IC50 value of 1.3 ± 0.2 μM. The amidic series 1a-i proves to be the most promising for future modulations, particularly at the triple bond level.
Synthesis, photophysical, and electrochemical properties of 2,5-diaryl-indolizines
Amaral, M?nica F.Z.J.,Deliberto, Laila A.,De Souza, Camila R.,Naal, Rose M.Z.G.,Naal, Zeki,Clososki, Giuliano C.
, p. 3249 - 3258 (2014/05/06)
A variety of novel 2,5-diaryl-indolizines have been prepared through the palladium-catalyzed cross-coupling reactions of organozinc reagents prepared from 2-aryl-indolizines with aromatic halides. The photophysical properties of representative compounds indicate that the 2,5-diaryl-indolizines are promising candidates to be used in optoelectronic devices and biomolecular labeling. In addition, cyclic voltammetry studies of some nitrophenyl-substituted indolizines have shown evidences of an oxidation process without the correspondent reduction peak suggesting a dimerization reaction.
A Synthetic Approach toward the Synthesis of Indolizines via 1,3-Dipolar Cycloaddition Reactions of Cycloimmonium Ylide
Tewari, Ram S.,Bajpai, Anita
, p. 505 - 507 (2007/10/02)
Dehydrohalogenation of N-(2-aroylmethyl)-2-picolinium and -4-picolinium bromide, prepared by the quaternization of corresponding bromide salt with triethylamine, afforded a highly reactive cycloimmonium ylide.Its 1,3-dipolar cycloaddition reactions with v
