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827579-70-4

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827579-70-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 827579-70-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,2,7,5,7 and 9 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 827579-70:
(8*8)+(7*2)+(6*7)+(5*5)+(4*7)+(3*9)+(2*7)+(1*0)=214
214 % 10 = 4
So 827579-70-4 is a valid CAS Registry Number.

827579-70-4Downstream Products

827579-70-4Relevant articles and documents

COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

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Page/Page column 64, (2010/06/19)

The invention relates to substituted 1,2-ethylenediamines of general formula (I), wherein the radicals R1-R13, A, B, L and i are as defined in the description and the claims. The invention also relates to the use thereof for treating Alzheimer's disease (AD) and similar diseases.

Discovery of oxadiazoyl tertiary carbinamine inhibitors of β-secretase (BACE-1)

Rajapakse, Hemaka A.,Nantermet, Philippe G.,Selnick, Harold G.,Munshi, Sanjeev,McGaughey, Georgia B.,Lindsley, Stacey R.,Young, Mary Beth,Lai, Ming-Tain,Espeseth, Amy S.,Shi, Xiao-Ping,Colussi, Dennis,Pietrak, Beth,Crouthamel, Ming-Chih,Tugusheva, Katherine,Huang, Qian,Xu, Min,Simon, Adam J.,Kuo, Lawrence,Hazuda, Daria J.,Graham, Samuel,Vacca, Joseph P.

, p. 7270 - 7273 (2007/10/03)

We describe the discovery and optimization of tertiary carbinamine derived inhibitors of the enzyme β-secretase (BACE-1). These novel non-transition-state-derived ligands incorporate a single primary amine to interact with the catalytic aspartates of the

1,3,5-SUBSTITUTED PHENYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

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, (2010/02/14)

The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

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