82759-10-2

Basic information

• Product Name: Benzenamine, 4-fluoro-5-(4-methyl-1-piperazinyl)-2-nitro-
• CAS NO: 82759-10-2
• Molecular Formula: C11H15FN4O2
• Molecular Weight: 254.264
• Mol File: 82759-10-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-fluoro-5-(4-methyl-1-piperazinyl)-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-fluoro-5-(4-methyl-1-piperazinyl)-2-nitro-(82759-10-2)
• EPA Substance Registry System: Benzenamine, 4-fluoro-5-(4-methyl-1-piperazinyl)-2-nitro-(82759-10-2)

Safety Data

• Hazardous Substances Data: 82759-10-2(Hazardous Substances Data)

Upstream product

• 877-90-7 N-(3-chloro-4-fluorophenyl)acetamide 
• 3863-11-4 3,4-difluoroaniline 
• 1662-21-1 N-(3,4-difluoro-2-nitrophenyl)acetamide 
• 81962-58-5 N-(3-chloro-4-fluoro-2-nitrophenyl)acetamide 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 109-01-3 1-methyl-piperazine 
• 104222-34-6 2-nitro-4-fluoro-5-chloroaniline 
• 78056-39-0 4,5-difluoro-2-nitroaniline 

Downstream Products

• 142335-19-1 methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-pyperzinyl)phenylsulfinyl>-3-cyclopropylamine 
• 142335-18-0 methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate 
• 142335-16-8 methyl 2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinylacetate 
• 142335-17-9 methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-dimethylaminoacrylate 
• 142335-15-7 methyl 2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylthioacetate 
• 142335-14-6 2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)aniline 

Relevant articles and documents

Design and synthesis of benzothiazole schiff bases of potential antitumor activity

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2- Amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]- Amine show specific anticancer cytotoxicity.

PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF

The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.

Synthesis of new 2-ferrocenyl-5-fluoro-6-(4-substituted-1-piperazinyl)-1H- benzimidazoles of potential biological interest

New substituted 2-ferrocenylbenzimidazole derivatives are prepared by the oxidation of corresponding Schiffs bases in situ, generated from corresponding 1,2-diamino-4-fluoro-5-(1-piperazinyl)benzenes and 2-ferrocenecarboxaldehyde using nitrobenzene.