82801-73-8

Basic information

• Product Name: ARG-LYS-ARG-ALA-ARG-LYS-GLU
• Synonyms: ARG-LYS-ARG-ALA-ARG-LYS-GLU;H-ARG-LYS-ARG-ALA-ARG-LYS-GLU-OH;CGMP DEPENDENT KINASE INHIBITOR PEPTIDE;[ALA32]-HISTONE H2B (29-35);PKG INHIBITOR;PROTEIN KINASE G INHIBITOR;RKRARKE;Alg-Lys-Arg-Ala-Arg-Lys-Glu
• CAS NO: 82801-73-8
• Molecular Formula: C38H74N18O10
• Molecular Weight: 943.11
• Product Categories: Protein Kinase
• Mol File: 82801-73-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.5 g/cm³
• Refractive Index: 1.657
• Storage Temp.: −20°C
• Water Solubility: Soluble in water at 1mg/ml
• CAS DataBase Reference: ARG-LYS-ARG-ALA-ARG-LYS-GLU(CAS DataBase Reference)
• NIST Chemistry Reference: ARG-LYS-ARG-ALA-ARG-LYS-GLU(82801-73-8)
• EPA Substance Registry System: ARG-LYS-ARG-ALA-ARG-LYS-GLU(82801-73-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 82801-73-8(Hazardous Substances Data)

Usage

Description

PKG inhibitor is a specific cGMP-dependent PKG inhibitor (Ki = 86 μM). This synthetic peptide is a nonphosphorylatable analog of a substrate corresponding to the serine-32 phosphorylation site in histone H2B. PKG inhibitor has been reported to block cGMP-dependent NMDA potentiation and nitric oxide-induced depression of GABA currents in cultured retinal amacrine cells.

Uses

A reversible substrate competitive inhibitor for protein kinase G. The sequence corresponds to a non-phosphorylatable analog of histone H2B.

InChI:InChI=1/C38H74N18O10/c1-21(29(59)52-26(13-8-20-50-38(46)47)33(63)54-24(11-3-5-17-40)34(64)56-27(35(65)66)14-15-28(57)58)51-31(61)25(12-7-19-49-37(44)45)55-32(62)23(10-2-4-16-39)53-30(60)22(41)9-6-18-48-36(42)43/h21-27H,2-20,39-41H2,1H3,(H,51,61)(H,52,59)(H,53,60)(H,54,63)(H,55,62)(H,56,64)(H,57,58)(H,65,66)(H4,42,43,48)(H4,44,45,49)(H4,46,47,50)/t21-,22-,23-,24-,25-,26-,27-/m0/s1