828271-40-5

Basic information

• Product Name: Cyclohexanecarboxylic acid, 4-ethyl-, methyl ester
• CAS NO: 828271-40-5
• Molecular Formula: C10H18O2
• Molecular Weight: 170.252
• Mol File: 828271-40-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclohexanecarboxylic acid, 4-ethyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanecarboxylic acid, 4-ethyl-, methyl ester(828271-40-5)
• EPA Substance Registry System: Cyclohexanecarboxylic acid, 4-ethyl-, methyl ester(828271-40-5)

Safety Data

• Hazardous Substances Data: 828271-40-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 619-64-7 p-ethylbenzoic acid 

Downstream Products

• 75839-87-1 cis-4-ethylcyclohexane<α,α-(2)H2>methanol 4'-methylbenzenesulfonate 
• 75839-88-2 trans-4-ethylcyclohexane<α,α-(2)H2>methanol 4'-methylbenzenesulfonate 
• 105746-45-0 N-[(trans-4-Ethylcyclohexyl)carbonyl]-D-phenylalanine 
• 75839-82-6 methyl cis-4-ethylcyclohexanecarboxylate 
• 75839-86-0 trans-4-ethyl-cyclohexanemethanol 
• 75839-85-9 cis-4-ethylcyclohexanemethanol 
• 75839-83-7 4-ethylcyclohexane<α,α-(2)H2>methanol 

Relevant articles and documents

N-(Cyclohexylcarbonyl)-D-phenylalanines and related compounds. A new class of oral hypoglycemic agents. 2

A series of analogues of N-(cyclohexylcarbonyl)-D-phenylalanine (5) have been synthesized and evaluated for their hypoglycemic activity. Relationships were studied between the activity and the three-dimensional structure of the acyl moiety, which was characterized by high-resolution 1H NMR spectroscopy and MNDO calculations. The role of the carboxyl group of the phenylalanine moiety was also studied by comparing the activities of the enantiomers, the decarboxyl derivative, the esters, and the amides of the phenylalanine derivatives. Thus, the structural requirements for possessing hypoglycemic activity was elucidated and a highly active compound, N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine (13) was obtained, which showed a 20% blood glucose decrease at an oral dose of 1.6 mg/kg in fasted normal mice.