828921-69-3Relevant articles and documents
A new synthetic analogue of thymidine, 7-(3-bromo-phenoxy)-thymidine, inhibits the proliferation of tumor cells
Kim, Kyung Noo,Lee, Jiyong,Kim, Dong Hoon,Yoo, Jong-Shin,Kwon, Ho Jeong
, p. 77 - 79 (2007/10/03)
The synthesis of new thymidine analogues and their biological activities are described. Modified thymidine analogues have been highlighted as useful agents for the treatment of cancer and viral diseases due to their potent biological activities. In the present study, we synthesized a new thymidine analogue, 7-(3-bromo-phenoxy)-thymidine (4a), as a potential lead for anti-tumor agent. Compound 4a potently inhibits HeLa cell proliferation with an IC 50 of 15 μM.