82900-57-0 Usage
Uses
BP 554 Maleate was used to study the methods for the classification and diagnosis of scoliosis.
Biological Activity
Selective 5-HT 1A agonist.
references
[1]. matsuda t, seong yh, aono h, et al. agonist activity of a novel compound, 1-[3-(3,4-methylenedioxyphenoxy)propyl]-4-phenyl piperazine (bp-554), at central 5-ht1a receptors. eur j pharmacol, 1989, 170(1-2): 75-82. [2]. galter d, unsicker k. sequential activation of the 5-ht1(a) serotonin receptor and trkb induces the serotonergic neuronal phenotype. mol cell neurosci, 2000, 15(5): 446-455.[3]. rauch a, rainer g, logothetis nk. the effect of a serotonin-induced dissociation between spiking and perisynaptic activity on bold functional mri. proc natl acad sci u s a, 2008, 105(18): 6759-6764.
Check Digit Verification of cas no
The CAS Registry Mumber 82900-57-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,2,9,0 and 0 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 82900-57:
(7*8)+(6*2)+(5*9)+(4*0)+(3*0)+(2*5)+(1*7)=130
130 % 10 = 0
So 82900-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2O3/c1-2-5-17(6-3-1)22-12-10-21(11-13-22)9-4-14-23-18-7-8-19-20(15-18)25-16-24-19/h1-3,5-8,15H,4,9-14,16H2
82900-57-0Relevant articles and documents
Discovery of LASSBio-772, a 1,3-benzodioxole N-phenylpiperazine derivative with potent alpha 1A/D-Adrenergic receptor blocking properties
Romeiro, Luiz A.S.,Da Silva Ferreira, Marcos,Da Silva, Leandro L.,Castro, Helena C.,Miranda, Ana L.P.,Silva, Cláudia L.M.,No?l, Franois,Nascimento, Jéssica B.,Araújo, Claudia V.,Tibiri?á, Eduardo,Barreiro, Eliezer J.,Fraga, Carlos A.M.
experimental part, p. 3000 - 3012 (2011/07/08)
We described herein the discovery of 1-(2-(benzo[d] [1,3]dioxol-6-yl)ethyl) -4-(2-methoxyphenyl) piperazine (LASSBio-772), as a novel potent and selective alpha 1A/1D adrenoceptor (AR) antagonist selected after screening of functionalized N-phenylpiperazine derivatives in phenylephrine-induced vasoconstriction of rabbit aorta rings. The affinity of LASSBio-772 for alpha 1A and alpha 1B AR subtypes was determined through displacement of [ 3H]prazosin binding. We obtained Ki values of 0.14 nM for the alpha 1A-AR, similar to that displayed by tamsulosin (Ki = 0.13 nM) and 5.55 nM for the alpha 1B-AR, representing a 40-fold higher affinity for alpha 1A-AR. LASSBio-772 also presented high affinity (KB = 0.025 nM) for the alpha 1D-AR subtype in the functional rat aorta assay, showing to be equipotent to tamsulosin (KB = 0.017 nM).