82936-42-3

Basic information

• Product Name: 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbonitrile
• Synonyms: 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbonitrile
• CAS NO: 82936-42-3
• Molecular Weight: 249.069
• Mol File: 82936-42-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbonitrile(82936-42-3)
• EPA Substance Registry System: 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbonitrile(82936-42-3)

Safety Data

• Hazardous Substances Data: 82936-42-3(Hazardous Substances Data)

Upstream product

• 23220-67-9 (E)-β-morpholino acrylonitrile 
• 2101-88-4 1-azido-4-bromobenzene 
• 65157-84-8 (E)-β-piperidino acrylonitrile 
• 920-37-6 2-Chloroacrylonitrile 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1422423-68-4 C₉H₅BrClN₃O 

Relevant articles and documents

Discovery of a novel 6,7-disubstituted-4-(2-fluorophenoxy)quinolines bearing 1,2,3-triazole-4-carboxamide moiety as potent c-Met kinase inhibitors

A series of 6,7-disubstituted-4-(2-fluorophenoxy)quinoline derivatives possessing 1,2,3-triazole-4-carboxamide moiety were designed, synthesized and evaluated for their in vitro cytotoxic activities against four typical cancer cell lines (A549, H460, HT-29, and MKN-45). Most compounds showed moderate-to-excellent antiproliferative activity. Compounds 32, 36, 37, 45, 51, and 52 were further examined for their inhibitory activity against c-Met kinase. The promising compound 37, with a c-Met IC50 value of 2.27 nM, was identified as a multitargeted receptor tyrosine kinase inhibitor. The analysis of their structure-activity relationships indicated that compounds with EWGs, especially chloro group, at 2-position on the phenyl ring (moiety B) have potent antitumor activity.

ADDITION DIPOLAIRE-1,3 AUX OLEFINS POTANT UNE SUBSTITUTION CAPTODATIVE: REACTIVITE COMPAREE DES α ET DES β AMINO ACRYLONITRILES VIS A VIS DES ARYLAZIDES.

Arylazides reacted with α amino-acrylonitriles 1 to produce 1-aryl-5-amono-triazoles, and with β amiono-acrylonitriles 2 to give 1-aryl-4-cyano-triazoles.Kinetics showed the Hammett ρ to be > ? and therefore, these reactions are controlled by LUMOazide-HOMOolefin interaction.Despite the captodative substitution in 1, the very small reactivity difference observed between the two isomers 1 and 2 (ΔΔE ca 500 cal.M-1) does'nt agree with a diradical intermediate.