82951-44-8Relevant articles and documents
Conjugate addition reactions of N -carbamoyl-4-pyridones and 2,3-dihydropyridones with grignard reagents in the absence of Cu(I) Salts
Guo, Fenghai,Dhakal, Ramesh C.,Dieter, R. Karl
, p. 8451 - 8464 (2013/09/24)
N-Boc- and N-ethoxycarbonyl-4-pyridones and the resulting 2,3-dihydropyridones undergo 1,4-addition reactions with Grignard reagents in the presence of chlorotrimethylsilane (TMSCl) or BF3·Et 2O in excellent yields. Copper catalysis is not required, and mechanistic considerations suggest that the reaction is proceeding by a conjugate addition pathway rather than by a pathway involving 1,2-addition to an intermediate pyridinium ion. TMSCl-mediated conjugate addition of Grignard reagents to 2-substituted-2,3-dihydropyridones gives the trans-2,6-disubstitued piperidinones stereoselectively, while cuprate reagents give either the trans or cis diastereomers or mixtures.
SYNTHESIS OF TRIFLATE AND CHLORIDE SALTS OF ALKYL N,N-BIS(2,2,2-TRIFLUOROETHYL)AMINES
Anderson, Gloria L.,Harruna, Issifu
, p. 111 - 114 (2007/10/02)
Triflate and chloride salts have been prepared in high yield by using the triflate displacement reaction.