82989-25-1

Basic information

• Product Name: TAZANOLAST
• Synonyms: TAZANOLAST;Butyl 3'-(1H-tetrazol-5-y1)oxanilate;Tazalest;Tazanol;TO-188;N-[3-(1H-Tetrazol-5-yl)phenyl]oxamidic acid butyl ester;Oxo[[3-(1H-tetrazol-5-yl)phenyl]amino]acetic acid butyl ester;WP-833
• CAS NO: 82989-25-1
• Molecular Formula: C13H15N5O3
• Molecular Weight: 289.29
• Mol File: 82989-25-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.343
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TAZANOLAST(CAS DataBase Reference)
• NIST Chemistry Reference: TAZANOLAST(82989-25-1)
• EPA Substance Registry System: TAZANOLAST(82989-25-1)

Safety Data

• Hazardous Substances Data: 82989-25-1(Hazardous Substances Data)

Usage

Description

Tazanolast is an orally active antiallergic agent that is effective in treating bronchial asthma and nasal allergy. It works by inhibiting IgG and IgE-mediated antigen-antibody reactions.

Uses

Used in Pharmaceutical Industry:
Tazanolast is used as a therapeutic agent for the treatment of bronchial asthma and nasal allergy. Its ability to inhibit IgG and IgE-mediated antigen-antibody reactions makes it a valuable drug for managing allergic reactions and improving the quality of life for patients suffering from these conditions.

Originator

Wakamoto (Japan)

InChI:InChI=1/C13H15N5O3/c1-2-3-7-21-13(20)12(19)14-10-6-4-5-9(8-10)11-15-17-18-16-11/h4-6,8H,2-3,7H2,1H3,(H,14,19)(H,15,16,17,18)

Upstream product

• 73732-51-1 5-(3-aminophenyl)-1H-tetrazole 
• 13318-13-3 oxalic acid monobutyl ester 

Relevant articles and documents

TETRAZOLE DERIVATIVES AND ALDOSE REDUCTASE INHIBITION THEREWITH

The present invention relates to an aldose reductase inhibitor having the following formula: R1 is a hydrogen atom or --A--COOR5 (A is an alkylene group having 1 to 4 carbon atoms and R5 is a hydrogen atom or a lower alkyl group), and R2, R3 and R4 are the same as or different from each other and selected from the group consisting of a hydrogen atom, a hydroxy group, a halogen atom, a carboxyl group, an alkyl group, an amide group, an amino group, an alkoxy group, an aryl group, an aryloxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, a nitro group, --NHCOCOOR6 (R6 is a hydrogen atom or a lower alkyl group), a mono or dialkylaminosulfonyl group, and a residual group having the following formula: (A and R5 are the same as in the above). The compounds defined in the above are excellent in aldose reductase inhibitory activity and low in toxicity. Therefore, those compounds are useful as a preventive agent and/or a remedy for diabetic complications such as neuropathy, retinopathy, nephropathy, cataracts and keratopathy