83-28-3Relevant articles and documents
Synthesis, characterization, in vitro antimicrobial and QSAR studies of diorganotin(IV) complexes of Schiff bases derived from 2-(3-methylbutanoyl)-1H-indene-1,3(2H)-dione and 4-substituted anilines
Khatkar, Priyanka,Asija, Sonika,Ahlawat, Aarti,Singh, Vikramjeet
, p. 207 - 218 (2019)
Abstract: A series of some new diorganotin(IV) complexes [R2SnLCl] was synthesized by the reaction of 2-(3-methylbutanoyl)-1H-indene-1,3(2H)-dione and 4-substituted anilines (p-OCH3, p-NO2, p-CH3, p-Cl) with R2SnCl2, (R=Me, Et, n-Bu, Ph) in 1:1 molar ratio. The structure of the Schiff bases and their complexes were characterized by IR, 13C, 1H, 119Sn NMR, and mass spectral techniques. The synthesized ligands and derived organotin complexes were evaluated in vitro against some bacterial strains, viz., Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Staphylococcus aureus and fungal strains, viz., Aspergillus flavus, Aspergillus niger, and Candida albicans by serial dilution method. The antimicrobial results revealed that organotin complexes showed a distinct escalation in biocidal activity. Phenyl and butyl complexes were found to be more intoxicating. Furthermore, we performed QSAR studies which explained the different factors affecting the enhancement in the bioactivity of the complexes.
Synthesis, antimicrobial evaluation, α-amylase inhibitory ability and molecular docking studies of 3-alkyl-1-(4-(aryl/heteroaryl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-ones
Khatri, Mohini,Mor, Satbir
, (2021/10/05)
A series of thiazole tethered indenopyrazoles has been synthesized and assayed for their antimicrobial and α-amylase inhibitory activities. Ciprofloxacin and Fluconazole were used as standard drugs for antibacterial and antifungal evaluation, respectively while Acarbose was used as standard reference for α-amylase inhibitory activity. The antimicrobial activity evaluation results revealed that derivative 3d showed highest potency against two Gram-positive bacterial strains (Bacillus subtilis and Staphylococcus aureus), two Gram-negative bacterial strains (Escherichia coli and Pseudomonas aeruginosa) with MIC values of 0.0541 μmol/mL, 0.0270 μmol/mL, 0.0270 μmol/mL, 0.0270 μmol/mL, respectively and two fungal strains (Candida albians and Aspergillus niger) with MIC values of 0.0067 μmol/mL and 0.0270 μmol/mL, respectively in comparison to the standard drugs Ciprofloxacin (MIC = 0.0094 μmol/mL) and Fluconazole (MIC = 0.0408 μmol/mL). Interestingly, all the compounds of the series except 3e exhibited better inhibitory activity against C. albicans with MIC value ranging from 0.0067 to 0.0297 μmol/mL than the standard drug Fluconazole. However, derivatives 3j with IC50 value of 0.79 μM and 3k with IC50 value of 0.46 μM were recognized as good α-amylase inhibitors as compared to the reference drug Acarbose (IC50 = 0.11 μM). Further, the docking studies were performed to support the results of biological activities.
Synthesis, Type II Diabetes Inhibitory Activity, and Antimicrobial Tests of Benzothiazole Derivatives Bridged with Indenedione by Methylenehydrazone
Mor,Sindhu,Khatri,Singh,Vasudeva,Panihar
, p. 1867 - 1873 (2019/11/02)
Benzothiazolyl hydrazones are synthesized and tested as hypoglycemic and antimicrobial agents. Condensation of 2-acyl-(1H)-indene-1,3(2H)-diones with 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles gives the corresponding hydrazones in high yields. Preliminary biological assay of the products reveals significant antidiabetic and antimicrobial activities. The α-amylase and α-glucosidase inhibition assay is used for determination of Type II diabetes inhibitory activity.
