83-93-2

Basic information

• Product Name: 5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID
• Synonyms: 5,6-DIHYDROBENZ[C]ACRIDINE-7-CARBOXYLIC ACID;5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID
• CAS NO: 83-93-2
• Molecular Formula: C₁₈H₁₃NO₂
• Molecular Weight: 275.3
• Mol File: 83-93-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 418.25°C (rough estimate)
• Flash Point: 253.7°C
• Appearance: /
• Density: 1.1884 (rough estimate)
• Vapor Pressure: 1.19E-10mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• CAS DataBase Reference: 5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID(83-93-2)
• EPA Substance Registry System: 5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID(83-93-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 83-93-2(Hazardous Substances Data)

Usage

General Description

5,6-Dihydro-benzo[c]acridine-7-carboxylic acid is a chemical compound with a molecular formula C17H13NO2. It is an organic compound that belongs to the class of benzo[c]acridine derivatives, which are known to exhibit various biological and pharmacological activities. 5,6-DIHYDRO-BENZO[C]ACRIDINE-7-CARBOXYLIC ACID may have potential applications in the field of medicinal chemistry and drug discovery due to its unique structure and properties. Further research is needed to explore its potential uses and potential benefits in various applications.

InChI:InChI=1/C18H13NO2/c20-18(21)16-13-7-3-4-8-15(13)19-17-12-6-2-1-5-11(12)9-10-14(16)17/h1-8H,9-10H2,(H,20,21)

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Relevant articles and documents

Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework

A novel class of potent and selective non-peptide neurokinin-3 (NK-3) receptor antagonists, featuring the 4-quinolinecarboxamide framework, has been designed based upon chemically diverse NK-1 receptor antagonists. The novel compounds 33-76, prompted by chemical modifications of the prototype 4, have been characterized by binding analysis using a membrane preparation of chinese hamster ovary (CHO) cells expressing the human neurokinin-3 receptors (hNK-3-CHO), and clear structure-activity relationships (SARs) have been established. From SARs, (R)-N-[α-(methoxycarbonyl)benzyl]-2- phenylquinoline-4-carboxamide (65, SB 218795, hNK-3-CHO binding K(i) = 13 nM) emerged as one of the most potent compounds of this novel class. Selectivity studies versus the other neurokinin receptors (hNK-2-CHO and hNK-1-CHO) revealed that 65 is about 90-fold selective for hNK-3 versus hNK-2 receptors (hNK-2-CHO binding K(i) = 1221 nM) and over 7000-fold selective versus hNK-1 receptors (hNK-1-CHO binding K(i) = >100 μM). In vitro functional studies in rabbit isolated iris sphincter muscle preparation demonstrated that 65 is a competitive antagonist of the contractile response induced by the potent and selective NK-3 receptor agonist senktide with a K(b) = 43 nM. Overall, the data indicate that 65 is a potent and selective hNK-3 receptor antagonist and a useful lead for further chemical optimization.