83056-78-4

Basic information

• Product Name: (S)-3-Methyl-2-oxo-iMidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester
• Synonyms: (S)-3-Methyl-2-oxo-iMidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester;(5S)-3-Methyl-2-oxo-1,5-imidazolidinedicarboxylic acid 5-(1,1-dimethylethyl) 1-(phenylmethyl) ester
• CAS NO: 83056-78-4
• Molecular Formula: C₁₇H₂₂N₂O₅
• Molecular Weight: 334.36698
• Mol File: 83056-78-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 101-102℃
• Appearance: /
• CAS DataBase Reference: (S)-3-Methyl-2-oxo-iMidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Methyl-2-oxo-iMidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester(83056-78-4)
• EPA Substance Registry System: (S)-3-Methyl-2-oxo-iMidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester(83056-78-4)

Safety Data

• Hazardous Substances Data: 83056-78-4(Hazardous Substances Data)

Usage

General Description

"(S)-3-Methyl-2-oxo-imidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester" is a compound that belongs in the chemical class of imidazolidines, which are molecules that have a five-membered ring with two nitrogen atoms and three carbon atoms. In this compound, one carbon atom in this ring system is substituted by an oxygen atom, turning it into a 2-oxo-imidazolidine. On the ring, there are two carboxylic acid residues which form ester bonds with other groups. On 1-position, the acid residue forms an ester with a benzyl group, which is a phenyl group attached to a CH2. At 5-position, the carboxylic acid residue makes an ester with a tert-butyl, which is a alkyl group consisting of a central carbon bonded to three methyl groups. This specific arrangement of these parts forms the unique structure of "(S)-3-Methyl-2-oxo-imidazolidine-1,5-dicarboxylic acid 1-benzyl ester 5-tert-butyl ester."

Upstream product

• 77999-24-7 (S)‐2‐oxoimidazolidine‐1,5‐dicarboxylate-5‐tert‐butyl ester-1‐benzyl ester 
• 74-88-4 methyl iodide 
• 59760-01-9 (S)-2-oxo-imidazolidine-1,5-dicarboxylic acid 1-benzyl ester 

Downstream Products

• 83056-79-5 (4S)-1-methyl-2-oxoimidazolidine-4-carboxylic acid t-butyl ester 
• 168292-63-5 (4S)-3-<(Benzyloxy)carbonyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid 
• 90157-23-6 benzyl (S)-5-(hydroxymethyl)-3-methyl-2-oxoimidazolidine-1-carboxylate 
• 168292-64-6 (4S)-3-<(Benzyloxy)carbonyl>-4-(tert-butoxymethyl)-1-methyl-2-oxoimidazolidine 
• 168292-68-0 (4S)-3-<(2R)-2-(N-Benzylamino)propionyl>-4-(tert-butoxymethyl)-1-methyl-2-oxoimidazolidine 
• 89396-94-1 Imidapril hydrochloride 
• 117605-23-9 tert-Butyl (4S)-3-<(2S)-2-amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate Hydrogenmaleate 
• 89371-38-0 tert-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 117605-21-7 tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate 
• 89371-44-8 (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid 
• 89460-20-8 tert-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylate 
• 117560-20-0 tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate 
• 89371-73-3 tert.-butyl (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-benzyloxycarbonyl-n-nonyl)amino]-n-butyryl}-2-oxo-imidazolidine-4-carboxylate 
• 117605-19-3 (4S)-3-<(2R)-2-amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid 

Relevant articles and documents

Studies on Angiotensin Converting Enzyme Inhibitors. 4. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of 3-Acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic Acid Derivatives

(4S)-1-Alkyl-3-acyl>-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods.Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed.The dicarboxylic acids 3a-n possessing S,S,S configuration showed potent in vitro ACE inhibitory activities with IC 50 values of 1.1x10-8-1.5x10-9 M.The most potent compound in this series, monoester 3p, had an ID 50 value of 0.24 mg/kg, po for inhibition of angiotensin I induced pressor response in normotensive rats and produced a dose-dependent decrease in systolic blood pressure of spontaneously hypertensive rats (SHRs) at doses of 1-10 mg/kg, po.

2-OXOIMIDAZOLIDINE DERIVATIVES

A 2-oxoimidazolidine derivative of the formula: STR1 wherein R 1 is lower alkyl or phenyl-lower alkyl and R 2 is lower alkyl or phenyl, and a process for preparation thereof are disclosed. Said 2-oxoimidazolidine derivative (I) or a pharmaceutically acceptable salt thereof is useful as a hypotensive agent.