83087-96-1

Basic information

• Product Name: 3'-O-mesyl-5'-O-trityl-2'-(4-tolylthio)uridine
• Synonyms: 3'-O-mesyl-5'-O-trityl-2'-(4-tolylthio)uridine
• CAS NO: 83087-96-1
• Molecular Weight: 350.395
• Mol File: 83087-96-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3'-O-mesyl-5'-O-trityl-2'-(4-tolylthio)uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-O-mesyl-5'-O-trityl-2'-(4-tolylthio)uridine(83087-96-1)
• EPA Substance Registry System: 3'-O-mesyl-5'-O-trityl-2'-(4-tolylthio)uridine(83087-96-1)

Safety Data

• Hazardous Substances Data: 83087-96-1(Hazardous Substances Data)

Upstream product

• 3736-77-4 2,2'-Anhydrouridine 
• 106-45-6 para-thiocresol 

Relevant articles and documents

Regioselective Mitsunobu Reaction of Partially Protected Uridine

Mitsunobu reaction of partially acylated uridine proceeds with high regioselectivity for intramolecular SN2 anhydro linkage closuring. Under the reaction conditions, an isomeric mixture of diacyl uridine derivatives with either free 2′- or 3′-hydroxyl group was transformed into a single cyclonucleosidic product, 2,2′-anhydro-3′,5′-di-O-acyluridine. This paper presents a possible mechanism of the reactions, the explanation of observed phenomenon based on semiempirical and density functional theory (DFT) calculations and possible utility of this synthetic pathway.

Reaction Between 2,2'-Anhydro-1-β-D-arabinofuranosyluracil and Thiolate Ions

2,2'-Anhydro-1-β-D-arabinofuranosyluracil (1a) reacts with the conjugate bases of thiophenol, toluene-4-thiol, ethanethiol, propane-1-thiol, 2-methylpropane-2-thiol and 4-methoxyphenylmethanethiol to give good to high yields of the c