83097-87-4

Basic information

• Product Name: BENZYL TRIFLUOROACETOACETATE
• Synonyms: BENZYL TRIFLUOROACETOACETATE
• CAS NO: 83097-87-4
• Molecular Formula: C₁₁H₉F₃O₃
• Molecular Weight: 246.183
• Mol File: 83097-87-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BENZYL TRIFLUOROACETOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL TRIFLUOROACETOACETATE(83097-87-4)
• EPA Substance Registry System: BENZYL TRIFLUOROACETOACETATE(83097-87-4)

Safety Data

• Hazardous Substances Data: 83097-87-4(Hazardous Substances Data)

Upstream product

• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 100-51-6 benzyl alcohol 
• 83643-84-9 methyl 4,4,4-trifluoroacetoacetate 

Downstream Products

• 87962-73-0 Benzyl 4-acetyl-5-methyl-3-trifluoromethylpyrrole-2-carboxylate 
• 852613-23-1 4-(3-cyano-phenyl)-2-hydroxy-5-oxo-2-trifluoromethyl-1,2,3,4,5,6,7,8-octahydro-quinoline-3-carboxylic acid benzyl ester 
• 874179-67-6 4-(3-chloro-phenyl)-2-hydroxy-6-methyl-2-trifluoromethyl-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid 3-benzyl ester 5-(2-cyano-ethyl) ester 
• 314776-25-5 5-benzyl 3-(2-cyanoethyl) 4-(3-chlorophenyl)-2-methyl-6-trifluoromethyl-1,4-dihydropyridine-3,5-dicarboxylate 
• 852613-33-3 4-(3-cyano-phenyl)-5-oxo-2-trifluoromethyl-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid benzyl ester 
• 87973-35-1 Benzyl 4-ethyl-5-methyl-3-trifluoromethylpyrrole-2-carboxylate 
• 87962-74-1 Benzyl 5-acetoxymethyl-4-ethyl-3-trifluoromethylpyrrole-2-carboxylate 

Relevant articles and documents

NEW ANALOGS AS ANDROGEN RECEPTOR AND GLUCOCORTICOID RECEPTOR MODULATORS

The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improve by modulation of androgen receptor and/or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases, cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.

Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels

Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity. In order to find specific N-type calcium channel blockers with the least effects on cardiovascular system, we performed structure-activity relationship study on APJ2708, which is a derivative of cilnidipine, and found a promising N-type calcium channel blocker 21b possessing analgesic effect in vivo with a 1600-fold lower activity against L-type calcium channels than that of cilnidipine.