83165-36-0

Basic information

• Product Name: (2S)-2,3-dibromopropan-1-ol
• CAS NO: 83165-36-0
• Molecular Weight: 217.888
• Mol File: 83165-36-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S)-2,3-dibromopropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2,3-dibromopropan-1-ol(83165-36-0)
• EPA Substance Registry System: (2S)-2,3-dibromopropan-1-ol(83165-36-0)

Safety Data

• Hazardous Substances Data: 83165-36-0(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 518315-61-2 (2S)-2,3-dibromopropyl N-([1,1'-biphenyl]-4-ylcarbonyl)-L-alaninate 
• 96-13-9 2,3-Dibromopropan-1-ol 
• 83165-32-6 mono-(+)-2,3-Dibromopropylamine d-tartrate salt 
• 83165-32-6 mono-(-)-2,3-Dibromopropylamine d-tartrate salt 

Downstream Products

• 51594-57-1 (R)-3-bromo-1,2-epoxypropane 

Relevant articles and documents

Preparation of (+)- and (-)-2,3-Dibromo-1-propanols

The enantiomers of 2,3-dibromo-1-propanol were obtained by diazotization of the diastereomeric d-tartrate salts of 2,3-dibromopropylamine.The products of the reaction contained approximately 13percent of the secondary alcohol 1,3-dibromo-2-propanol which was separated by either column chromatography on silica gel or preparative GLC to obtain the primary alcohols (+)-2,3-dibromo-1-propanol (26D +13.8 deg) and (-)-2,3-dibromo-1-propanol (24D -12.8 deg).NMR and EI mass spectra of the primary and secondary dibromopropanols clearly distinguished the structuralisomers from one another.The optical isomers will be used to examine possible stereoselective differences in mutagenic potency, since 2,3-dibromo-1-propanol is a mutagenic metabolite of the potent mutagen and carcinogen tris(2,3-dibromopropyl) phosphate.

Degradation of 2,3-Dichloro-1-propanol by a Pseudomonas sp.

A bacterium that assimilates 2,3-dichloro-1-propanol was isolated from soil by enrichment culture.The strain was identified as Pseudomonas sp. by the taxonomic studies.The strain converted 2,3-dichloro-1-propanol to 3-chloro 1,2-propanediol, releasing chloride ions.The conversion was stereospecific because the residual 2,3-dichloro-1-propanol and formed 3-chloro-1,2-propanediol gave optical rotation.The resting cells converted various halohydrins to the dehalogenated alcohols, and cell-free extracts had strong epoxyhydrolase activity.These results indicated that the strain assimilated 2,3-dichloro-1-propanol via 3-chloro-1,2-propanediol, glycidol and glycerol.The possibility to manufacture optically active 2,3-dichloro-1-propanol is discussed.