83171-49-7

Basic information

• Product Name: 3-Fluoro-5-iodoaniline
• Synonyms: 3-CHLORO-5-IODOANILINE
• CAS NO: 83171-49-7
• Molecular Formula: C₆H₅ClIN
• Molecular Weight: 253.46807
• Mol File: 83171-49-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 3-Fluoro-5-iodoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-5-iodoaniline(83171-49-7)
• EPA Substance Registry System: 3-Fluoro-5-iodoaniline(83171-49-7)

Safety Data

• Hazardous Substances Data: 83171-49-7(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-iodoaniline is a chemical compound with the molecular formula C6H5FIN. It is a substituted aniline with a fluorine atom at the 3-position and an iodine atom at the 5-position on the benzene ring. 3-Fluoro-5-iodoaniline is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also utilized in organic chemistry reactions as a building block for the creation of more complex molecules. 3-Fluoro-5-iodoaniline is classified as a potentially hazardous chemical and should be handled with care in a controlled laboratory setting.

Upstream product

• 861547-81-1 1,2-dichloro-3-iodo-5-nitro-benzene 
• 123158-76-9 1-chloro-3-iodo-5-nitrobenzene 
• 123158-75-8 2-amino-5-chloro-3-nitrophenyliodide 
• 89-63-4 4-Chloro-2-nitroaniline 
• 99-54-7 3,4-dichloronitrobenzene 
• 861609-74-7 2-chloro-6-iodo-4-nitroaniline 
• 121-87-9 2-Chloro-4-nitroaniline 
• 7439-89-6 iron 
• 146512-91-6 5-nitro-4-chloro-2-iodoaniline 

Downstream Products

• 139422-22-3 N-(3-chloro-5-iodophenyl)(hydroxyimino)acetamide 
• 139422-25-6 2-amino-4-chloro-6-iodobenzoic acid 
• 139422-27-8 methyl 2-amino-4-chloro-6-iodobenzoate 
• 139422-28-9 4-Chloro-2-(2-ethoxycarbonyl-acetylamino)-6-iodo-benzoic acid methyl ester 

Relevant articles and documents

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Kynurenic Acid Derivatives. Structure-Activity Relationships for Excitatory Amino Acid Antagonism and Identification of Potent and Selective Antagonists at the Glycine Site of the N-Methyl-D-aspartate Receptor

Derivatives of the nonselective excitatory amino acid antagonist kynurenic acid (4-oxo-1,4-dihydroquinoline-2-carboxylic acid, 1) have been synthesized and evaluated for in vitro antagonist activity at the excitatory amino acid receptors sensitive to N-me