83249-04-1

Basic information

• Product Name: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid
• Synonyms: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid
• CAS NO: 83249-04-1
• Molecular Formula: C₁₂H₁₂O₂
• Molecular Weight: 188.22248
• Mol File: 83249-04-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid(83249-04-1)
• EPA Substance Registry System: 3-phenylbicyclo[1.1.1]pentane-1-carboxylic acid(83249-04-1)

Safety Data

• Hazardous Substances Data: 83249-04-1(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 134938-21-9 1-phenylbicyclo<1.1.1>pentane 
• 127321-10-2 1-iodo-3-phenylbicyclo<1.1.1>pentane 
• 65862-03-5 methyl 3-phenyl-2,2-dichlorobicyclo<1.1.1>pentanecarboxylate 
• 83249-09-6 methyl 3-phenylbicyclo<1.1.1>pentane-1-carboxylate 
• 591-50-4 iodobenzene 
• 35634-10-7 [1.1.1]propellane 
• 431-03-8 dimethylglyoxal 
• 311-75-1 bicyclo[1.1.1]pentane 
• 105542-98-1 1,3-bisiodobicyclo[1.1.1]pentane 
• 23761-26-4 3-phenyl-3-hydroxycyclobutane-1-carboxylic acid 
• 23761-27-5 3-phenyl-3-chlorocyclobutane-1-carboxylic acid 
• 30493-91-5 methyl 3-chloro-3-phenylcyclobutane-1-carboxylate 
• 30493-96-0 methyl 3-phenylbicyclo<1.1.0>butanecarboxylate 

Downstream Products

• 83249-09-6 methyl 3-phenylbicyclo<1.1.1>pentane-1-carboxylate 
• 156329-79-2 3-Phenyl-bicyclo[1.1.1]pentane-1-carboxylic acid 2-thioxo-2H-pyridin-1-yl ester 
• 83249-05-2 3-acetyl-1-phenylbicyclo<1.1.1>pentane 
• 83249-11-0 1-phenylbicyclo<1.1.1>pent-3-ylamine hydrochloride 
• 134938-21-9 1-phenylbicyclo<1.1.1>pentane 
• 102410-96-8 3,3'-diphenyl-1,1'-bi(bicyclo[1.1.1]pentane) 
• 156329-80-5 3-(p-nitrophenyl)bicyclo<1.1.1>pentane-1-carboxylic acid 
• 56842-95-6 bicyclo<1.1.1>pentane-1,3-dicarboxylic acid 
• 784093-32-9 3-phenylbicyclo[1.1.1]pentan-1-amine 
• 83249-12-1 3-nitro-1-phenylbicyclo<1.1.1>pentane 
• 127321-10-2 1-iodo-3-phenylbicyclo<1.1.1>pentane 
• 159600-58-5 1-iodo-2-(p-nitrophenyl)bicyclo<1.1.1>pentane 
• 159600-55-2 methyl 3-(p-nitrophenyl)bicyclo<1.1.1>pentyl-1-carboxylate 
• 112043-92-2 1-bromo-3-phenylbicyclo<1.1.1>pentane 

Relevant articles and documents

ANALGESIC COMPOUNDS

Disclosed herein are compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), methods of synthesizing compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It), and methods of using compounds of Formulae (la), (lb), (Ic), (Id), (le), (If), (Ig), (Ih), (Ik), (Im), (In), (Io), (Ip), (Iq), (Ir), (Is) and (It) as an analgesic.

COMPOUNDS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.

Synthesis of Some Bridgehead-Bridgehead-Disubstituted Bicyclopentanes

The synthesis of a wide variety of 1,3-disubstituted bicyclopentanes is described, with particular emphasis on the generation of a series of 3-X-substituted bicyclopentyl bromides required for solvolytic studies.Functional group manipulation at the bridgehead was readily accomplished in the majority of cases by radical processes; in some instances, transformations were effected via carbanionic-type intermediates.