83260-96-2

Basic information

• Product Name: 4-CHLOROQUINALDINE HCL
• Synonyms: 4-CHLOROQUINALDINE HCL;4-CHLORO-2-METHYL-QUINOLINE, HYDROCHLORIDE;LABOTEST-BB LTBB004603
• CAS NO: 83260-96-2
• Molecular Formula: C10H9Cl2N
• Molecular Weight: 214.09116
• Mol File: 83260-96-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLOROQUINALDINE HCL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROQUINALDINE HCL(83260-96-2)
• EPA Substance Registry System: 4-CHLOROQUINALDINE HCL(83260-96-2)

Safety Data

• Hazardous Substances Data: 83260-96-2(Hazardous Substances Data)

Usage

General Description

4-CHLOROQUINALDINE HCL is a chemical compound that is a derivative of quinoline. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. The hydrochloride salt form of 4-CHLOROQUINALDINE is more stable and soluble in water, making it easier to handle and use in various chemical processes. It is widely used in the production of antimalarial and antiparasitic drugs, as well as in the synthesis of dyes and other organic compounds. 4-CHLOROQUINALDINE HCL is an important intermediate in the pharmaceutical and chemical industries, and its versatility and wide range of applications make it a valuable compound in the field of organic chemistry.

InChI:InChI=1/C10H8ClN.ClH/c1-7-6-9(11)8-4-2-3-5-10(8)12-7;/h2-6H,1H3;1H

Upstream product

• 83260-84-8 5-(4-Chloro-quinolin-2-yl)-2,2-dimethyl-[1,3]dioxane-4,6-dione 
• 4637-59-6 4-Chloroquinoline N-oxide 

Downstream Products

• 99361-09-8 4-iodo-2-methylquinoline 

Relevant articles and documents

Studies on Tertiary Amine Oxides. LXXV. Reactions of Aromatic N-oxides with Meldrum's Acid in the Presence of Acetic Anhydride

Reactions of quinoline, lepidine, 4-chloro-, 4-methoxy- and 4-morpholino-quinoline 1-oxides (1a-e) with Meldrum's acid (2) in acetic anhydride smoothly occurred at room temperature to afford the corresponding 5-(2-quinolyl)-Meldrum's acids (3a-e) in good yields.On the other hand, when the reactions were carried out in dimethylformamide containing 1.2 eq acetic anhydride the N-ylides (4a-e) were produced; while the reactions of 1a, d, e yielded only N-ylides 4a, d, e, 4b, c were formed along with smaller amounts of 3b, c in the reactions of 1b, c. 3-Bromoquinoline 1-oxide (1f) gave only the N-ylide (4f) and isoquinoline 2-oxide (6) gave the 1-substituted isoquinoline (7) independently of the reaction conditions.Further, 5-alkyl-Meldrum's acids (8a-c) also reacted readily with 1a in acetic anhydride to give the corresponding 2-substituted quinolines (9a-c) in good yields.Heating of 3a, b with conc. hydrochloric acid, 10percent hydrochloric acid or methanol containing 10percent hydrogen chloride gave 2-methylquinolines (10a, b), 2-quinolineacetic acids (11a, b) or their methyl esters (12a, b), respectively.Similarly, 9a-c afforded 2-alkylquinolines (14a-c) in good yields upon being refluxed with conc. hydrochloric acid.Keywords--aromatic N-oxide; Meldrum's acid; 5-(2-quinolyl)-Meldrum's acid; quinolinium-5-Meldrum's acid ylide; 5-(1-isoquinolyl)-Meldrum's acid; 2-alkylquinoline; 2-quinolineacetic acid; nucleophilic reaction; regioselectivity