832711-04-3

Basic information

• Product Name: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 832711-04-3
• Molecular Weight: 580.056
• Mol File: 832711-04-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione(832711-04-3)
• EPA Substance Registry System: 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-(3-hydroxyphenyl)-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione(832711-04-3)

Safety Data

• Hazardous Substances Data: 832711-04-3(Hazardous Substances Data)

Upstream product

• 832711-51-0 3-[2(R)-tert-butoxycarbonylamino-2-phenylethyl]-5-bromo-1-[2-bromo-6-fluorobenzyl]-6-methylpyrimidine-2,4(1H,3H)-dione 
• 214360-76-6 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol 

Relevant articles and documents

PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure formula (I) wherein R1a, R1b, R2a, R2b, R3, R4, R5, R6, R7 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.