83303-93-9

Basic information

• Product Name: 1-fluoronorhexestrol
• Synonyms: 1-fluoronorhexestrol
• CAS NO: 83303-93-9
• Molecular Formula: C₁₇H₁₉FO₂
• Molecular Weight: 274.33
• Mol File: 83303-93-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-fluoronorhexestrol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-fluoronorhexestrol(83303-93-9)
• EPA Substance Registry System: 1-fluoronorhexestrol(83303-93-9)

Safety Data

• Hazardous Substances Data: 83303-93-9(Hazardous Substances Data)

Upstream product

• 83303-92-8 (2R*,3S*)-2,3-bis<4-<(trifluoromethanesulfonyl)oxy>phenyl>-1-pentyl 
• 79568-19-7 (2R*,3S*)-2,3-bis(4-hydroxyphenyl)-1-pentanol 

Relevant articles and documents

Nonsteroidal Estrogens: Synthesis and Estrogen Receptor Binding Affinity of Derivatives of (3R*,4S*)-3,4-Bis(4-hydroxyphenyl)hexane (Hexestrol) and (2R*,3S*)-2,3-Bis(4-hydroxyphenyl)pentane (Norhexestrol) Functionalized on the Side Chain

A series of nonsteroidal, side-chain functionalized estrogens based on (3R*,4S*)-3,4-bis(4-hydroxyphenyl)hexane (hexestrol) and (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentane (norhexestrol) has been prepared; these include amide, diazo ketone, ester, alcohol, ketone, fluoro,bromo, iodo, and saturated hydrocarbon derivatives.Analysis of the binding affinity of these compounds to the uterine estrogen receptor, measured by competitive binding assay, reveals trends that can be related to the steric size, the hydrophobicity, and the hydrogen bond accepting character of the side-chain substituents.Comparison of binding affinities between norhexestrol and hexestrol derivatives indicates that, in general, the norhexestrols show significantly higher receptor binding affinities, making this series of compounds ideally suited as functional probes for the estrogen receptor.